AI Article Synopsis
- The study explored how MK-801, a noncompetitive NMDA receptor antagonist, influences seizures triggered by hyperbaric oxygen in rats, focusing on cerebral blood flow changes.
- MK-801 showed a biphasic effect: lower doses (0.1-4 mg/kg) shortened the time to seizure onset, while a higher dose (8 mg/kg) had no impact on latency or seizure duration.
- Unlike MK-801, another NMDA receptor antagonist called AP-7 did not affect seizure latency or cerebral blood flow, indicating differences in how these drugs work.
Article Abstract
The effect of the noncompetitive N-methyl-d-aspartate (NMDA)-receptor antagonist MK-801 on seizures induced by hyperbaric oxygen in relation to changes in cerebral blood flow (CBF) was investigated. Rats were injected with MK-801 (0.005-8 mg/kg) 30 min before exposure to 100% O2 at 5 atm (gauge pressure). MK-801 administration resulted in a biphasic response in seizure latency. Doses of 0.1-4 mg/kg significantly decreased time to EEG and motor seizures, while 8 mg/kg had no effect on seizure latency. MK-801 had no effect on seizure duration. In a dose range 0.1-8 mg/kg MK-801 increased CBF in awake animals, which might be responsible for the decreased seizure latency. The gradual increase in seizure latency with increasing MK-801 doses suggests involvement of an additional factor probably related to the drug's anticonvulsive effect. Unlike MK-801, a competitive NMDA receptor antagonist, AP-7, at a dose 250 mg/kg had no effect on latency to seizures or CBF.
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| http://dx.doi.org/10.1006/taap.1998.8447 | DOI Listing |
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