In 43 patients the effect of low concentrations of methoxyflurane on the renal function was studied. The blood levels of urea, creatinine, uric acid, sodium and potassium, and specific weight of urine was determined. It was found that the anaesthetic technique used and methoxyflurane concentrations in the range of 0.2-0.5 vol% caused no abnormalities in renal function. It seems that methoxyflurane in low concentrations (0.2-0.5 vol%) is the best method of anaesthesia with this agent, with the simultaneous use of a nitrous oxide-oxygen mixture and controlled ventilation.
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