It is shown that the oxidation of membrane protein SH-groups of human erythrocytes by diamide leads to the intensification of vesiculation and the formation on the cell surface of "senescent antigens". These processes were studied during prolonged incubation of erythrocytes at 37 degrees C in the absence of glucose. It was found that the formation of vesicules in ATP-depleted cells correlated with the appearance of "senescent antigens" (r = 0.9, p < 0.01). The oxidation of protein SH-groups takes place at the early stages of vesiculation and strengthening of autologous immunoglobulin binding, indicating that the oxidation of the other groups of membrane proteins plays the leading role in the modification of surface properties.
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