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Probiotic-rich fermented milk from IIA-1A5: Effects on pregnancy health in the animal model.
Narra J
December 2024
Department of Animal Production and Technology, Faculty of Animal Science, Institut Pertanian Bogor, Bogor, Indonesia.
Previous studies of IIA-1A5 have shown its potential as a probiotic in modulating gut microbiota and providing health benefits; however, its effects during pregnancy remain underexplored. The aim of this study was to assess the safety of fermented milk enriched with IIA-IA5 in pregnant mice. An experimental study was conducted at Universitas Andalas, Padang, Indonesia.
View Article and Find Full Text PDFAn Unusual Case of Sternal Osteomyelitis and Purulent Mediastinitis After a Traumatic Sternal Body Fracture.
Cureus
November 2024
Department of Surgery, Nassau University Medical Center, East Meadow, USA.
A 67-year-old female presented to the emergency department after falling on her chest. On initial presentation, her chest wall was tender to palpation with mild overlying ecchymosis. Initial imaging demonstrated a sternal body fracture with minimal retrosternal hematoma.
View Article and Find Full Text PDFMusculoskeletal infections associated with species: a case series.
J Bone Jt Infect
September 2024
Division of Public Health, Infectious Diseases and Occupational Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
: is an uncommon pathogen that has been reported to infect musculoskeletal structures. However, studies are largely limited to case reports, and little is known regarding management and outcomes of these infections. : We performed a multicenter retrospective cohort study of adults with culture-confirmed musculoskeletal infections at three Mayo Clinic centers in Arizona, Florida, and Minnesota from November 2011 through April 2022.
View Article and Find Full Text PDFA rare complication of blood culture-negative infective endocarditis on tricuspid valve: case report.
Eur Heart J Case Rep
November 2024
Azienda Ospedaliera Universitaria Policlinico 'G. Rodolico-San Marco', Via S. Sofia 78, 95100 Catania, Italy.
Background: Endocarditis is an infectious disease, with an incidence of ∼15 cases per 100 000 people, affecting the tricuspid valve in 10% of cases. Infective endocarditis with negative blood cultures (BCNIE) accounts for more than 20% of cases of infective endocarditis. Perivalvular extension of the infection represents the most detrimental complications of BCNIE.
View Article and Find Full Text PDFIL-4 promotes chondrogenesis of bone marrow mesenchymal stem cells and blockade of IL-4Rα retards the endochondral ossification during rat embryonic bone development.
Basic Clin Pharmacol Toxicol
December 2024
Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China.
Article Synopsis
- The study investigates the roles of interleukin-4 (IL-4) and its receptor (IL-4Rα) in bone formation processes like chondrogenic differentiation and ossification during embryonic development.
- Using an anti-IL-4Rα monoclonal antibody, researchers found that IL-4 significantly promotes the differentiation of rat bone marrow mesenchymal stem cells (BMSCs) into cartilage-forming cells (chondrocytes).
- The research revealed that blocking IL-4Rα in pregnant rats led to abnormal fetal bone development, such as incomplete ossification in the sternum and long bones, indicating that IL-4/IL-4Rα signaling is crucial for proper bone development
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