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Osteopontin as a Novel Biomarker in Distinguishing Chronic Rhinosinusitis with Nasal Polyp Endotypes and Predicting Disease Severity.
Int Arch Allergy Immunol
November 2024
Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Introduction: The objective of this study was to ascertain the predictive value of osteopontin (OPN), a cytokine with pro-inflammatory properties implicated in inflammatory and allergic conditions, in nasal secretions for the identification of chronic rhinosinusitis with nasal polyp (CRSwNP) endotypes and the assessment of disease severity.
Methods: A cohort comprising 81 individuals diagnosed with CRSwNP was enrolled, which included 37 subjects with the non-eosinophilic CRSwNP and 44 subjects with the eosinophilic CRSwNP (eCRSwNP), alongside 32 healthy controls (HCs). Nasal secretions and tissue samples were collected from all participants.
"Anchoring Capture" Effect Mimicking Proline in Hardy Deep-Sea Fish to Stabilize the Zinc Anode with Lower Operating Temperature.
Small
January 2025
Department of Chemistry and the Tsinghua Center for Frontier Polymer Research, Tsinghua University, Beijing, 100084, China.
The low plating/stripping efficiency of zinc anodes, dendrite growth, and high freezing points of aqueous solutions hinder the practical application of aqueous zinc-ion batteries. This paper proposes a zwitterionic permeable network solid-state electrolyte based on the "anchor-capture" effect to address these problems by incorporating proline (Pro, a biological antifreeze agent) into the electrolyte. Extensive validation tests, Quantum Chemistry (QC) calculations, Molecular Dynamics (MD) Simulations, and ab initio molecular dynamics simulations consistently indicate that the amino groups in proline adsorb onto the Zn metal surface, stabilizing the zinc anode-electrolyte interface, suppressing side reactions from water decomposition, and homogenizing zinc-ion flux.
View Article and Find Full Text PDFBuilding Stable Solid-State Potassium Metal Batteries.
Adv Mater
June 2024
School of Physics and Electronics, Hunan University, Changsha, 410082, P. R. China.
Solid-state potassium metal batteries (SPMBs) are promising candidates for the next generation of energy storage systems for their low cost, safety, and high energy density. However, full SPMBs are not yet reported due to the K dendrites, interfacial incompatibility, and limited availability of suitable solid-state electrolytes. Here, stable SPMBs using a new iodinated solid polymer electrolyte (ISPE) are presented.
View Article and Find Full Text PDFThe pro-sequence of parathyroid hormone prevents premature amyloid fibril formation.
FEBS Lett
April 2023
Institute of Physics, Biophysics, Martin-Luther-University Halle-Wittenberg, Germany.
The parathyroid hormone (PTH) regulates the calcium and phosphate level in blood after secretion from parathyroid chief cells. The pre- and pro-sequences of precursor preproPTH get cleaved during PTH maturation. In secretory granules, PTH forms functional amyloids.
View Article and Find Full Text PDFSpacer Matters: All-Peptide-Based Ligand for Promoting Interfacial Proteolysis and Plasmonic Coupling.
Nano Lett
November 2022
Department of NanoEngineering, University of California, San Diego, La Jolla, California 92093, United States.
Plasmonic coupling nanoparticle assembly is a popular signal-generation method in bioanalytical sensors. Here, we customized an all-peptide-based ligand that carries an anchoring group, polyproline spacer, biomolecular recognition, and zwitterionic domains for functionalizing gold nanoparticles (AuNPs) as a colorimetric enzyme sensor. Our results underscore the importance of the polyproline module, which enables the SARS-CoV-2 main protease (M) to recognize the peptidic ligand on nanosurfaces for subsequent plasmonic coupling Coulombic interactions.
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