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Aminophylline at clinically relevant concentrations affects inward rectifier potassium current in healthy porcine and failing human cardiomyocytes in a similar manner.
Biomed Pharmacother
December 2024
ICRC, St. Anne's University Hospital, Pekařská 53, Brno 602 00, Czech Republic; 1st Department of Internal Medicine, Cardio-Angiology, Faculty of Medicine, Masaryk University, Pekařská 53, Brno 602 00, Czech Republic.
Article Synopsis
- - Aminophylline, a medication often used for severe asthma, can cause arrhythmias, but the exact reasons are not clear
- - In research, aminophylline significantly inhibited the inward rectifier potassium current in both healthy pig heart cells and failing human heart cells at different concentrations
- - The study found that aminophylline prolonged action potential duration in porcine heart cells, indicating its potential role in causing arrhythmias, suggesting further exploration of its effects on other ionic currents is necessary
Article Synopsis
- Fluid overload in pediatric cardiac surgery can lead to serious health issues, and managing it is challenging, with traditional methods potentially harming kidney function.
- This study evaluated aminophylline's effect on fluid balance, urine output, and kidney function in pediatric patients after cardiac surgery, analyzing data from 72 patients who received the drug between September 2022 and December 2023.
- Results showed that aminophylline significantly reduced fluid balance by 115% and doubled urine output in the 24 hours following administration without negatively impacting kidney function markers, indicating it is a safe option for these patients.
[ Formula alleviates airway inflammation in rats with chronic obstructive pulmonary disease and kidney deficiency syndrome by inhibiting ferroptosis regulating the Nrf2/SLC7A11/GPX4 signaling pathway].
Nan Fang Yi Ke Da Xue Xue Bao
October 2024
Anhui Province Key Laboratory of the Application and Transformation of Traditional Chinese Medicine in the Prevention and Treatment of Major Pulmonary Diseases, Hefei 230031, China.
Objective: To investigate the effects of Formula (SQTSF) for alleviating airway inflammation in rats with both chronic obstructive pulmonary disease (COPD) and lung-kidney deficiency syndrome and explore its therapeutic mechanism.
Methods: Forty-eight SD rats were randomly divided into control group, model group, low-, medium-, and high-dose SQTSF groups, and aminophylline (APL) group. In all but the control group, rat models of COPD with lung-kidney deficiency syndrome were established and treated with saline, SQTSF or APL daily gavage as indicated (starting from day 30).
Salbutamol attenuates arrhythmogenic effect of aminophylline in a hPSC-derived cardiac model.
Sci Rep
November 2024
Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
The combination of aminophylline and salbutamol is frequently used in clinical practice in the treatment of obstructive lung diseases. While the side effects (including arrhythmias) of the individual bronchodilator drugs were well described previously, the side effects of combined treatment are almost unknown. We aimed to study the arrhythmogenic potential of combined aminophylline and salbutamol treatment in vitro.
View Article and Find Full Text PDFTheophylline derivatives promote primordial follicle activation via cAMP-PI3K/Akt pathway and ameliorate fertility deficits in naturally aged mice.
Int J Biol Sci
October 2024
The Innovation Centre of Ministry of Education for Development and Diseases, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, 510006, China.
In elderly women and patients with premature ovarian insufficiency (POI), activating their remaining dormant primordial follicles is challenging. In this study, we found that phosphodiesterase (PDE) subtypes were expressed mainly in primordial follicle oocytes. The specific PDE inhibitors and theophylline derivatives (aminophylline, dyphylline, and enprofylline) activated primordial follicles in neonatal mice by ovary culture and intraperitoneal injection.
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