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Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning.
Dev Biol
December 2014
Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands.
Unlabelled: Notch signaling plays an acknowledged role in bile-duct development, but its involvement in cholangiocyte-fate determination remains incompletely understood. We investigated the effects of early Notch2 deletion in Notch2(fl/fl)/Alfp-Cre(tg/-) ("Notch2-cKO") and Notch2(fl/fl)/Alfp-Cre(-/-) ("control") mice. Fetal and neonatal Notch2-cKO livers were devoid of cytokeratin19 (CK19)-, Dolichos-biflorus agglutinin (DBA)-, and SOX9-positive ductal structures, demonstrating absence of prenatal cholangiocyte differentiation.
View Article and Find Full Text PDFRadical surgery of left-sided klatskin tumors.
HPB (Oxford)
May 2010
Aichi Cancer Center, Nagoya, Japan.
Left-sided cholangiocarcinoma includes hilar cholangiocarcinoma (HC), predominantly involving the left hepatic duct, and intrahepatic cholangiocarcinoma (ICC) in the left liver. Left hepatectomy, or left hepatic trisectionectomy, is indicated as radical surgery of left-sided HC or ICC with or without hilar bile duct invasion. Left lateral sectionectomy, or left medial sectionectomy, is performed for the small mass-forming type ICC.
View Article and Find Full Text PDFFibrate for treatment of primary biliary cirrhosis.
Hepatol Res
October 2007
Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku, Kochi, Japan.
Recent studies of the effectiveness of ursodeoxycholic acid (UDCA) therapy in patients with primary biliary cirrhosis (PBC) reported that UDCA therapy did not necessarily stop the progression of liver fibrosis in all patients, even those with early stage PBC. Thus, there is a need for more effective treatments that could prevent asymptomatic PBC from progressing to the icteric stage. Bezafibrate is effective in approximately two-thirds of non-icteric patients who have not shown a complete response to UDCA.
View Article and Find Full Text PDFPediatric presentations of leptospirosis.
Indian J Pediatr
October 2002
Kanchi Kamakoti Childs Trust Hospital, Nungambakkam, Chennai, India. saralarajaje@yahoocom
Objective: Leptospirosis in children is an often under diagnosed condition due to the non specificity of the presentations except for the classical Weil's disease.
Methods: Children presenting with symptoms and signs suggestive of Leptospirosis were included in the study. Diagnostic criteria were fever, myalgia, conjunctival suffusion, Jaundice, headache, altered sensorium, seizures, bleeding manifestation and oliguria.
[The current problems in the epidemiology and prevention of enteric viral hepatitis in Russia].
Zh Mikrobiol Epidemiol Immunobiol
April 1995
The presence of great differences in the activity of the epidemic process of hepatitis A (HA) in some regions of Russia is shown and the data necessary for establishing the structure of HA foci in groups of children, as well as the proportion of different forms of the disease registered in such foci (the icteric form in 22.7% of patients, the obliterated form in 11.3% of patients, the nonicteric form in 45.
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