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Inhibitory Effects of L. Extract on the Female Hormones Based on Bioautography-HPTLC-MS.
Iran J Pharm Res
September 2024
Protein Research Center, Shahid Beheshti University, Tehran, Iran.
Background: Hormonal imbalances related to women's health, physical activity, and fluctuations are prevalent metabolic disorders in several nations and have significantly impacted women's health for an extended period. The application of individual or combined botanical extracts in traditional, alternative, and complementary medicine is employed to manage and alleviate these issues.
Objectives: The objective of this study is to examine the suppressive properties of horehound ( L.
Hormone Signaling in Breast Development and Cancer.
Adv Exp Med Biol
January 2025
Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Hormones control normal breast development and function. They also impinge on breast cancer (BC) development and disease progression in direct and indirect ways. The major ovarian hormones, estrogens and progesterone, have long been established as key regulators of mammary gland development in rodents and linked to human disease.
View Article and Find Full Text PDFCD-44 targeted nanoparticles for combination therapy in an in vitro model of triple-negative breast cancer: Targeting the tumour inside out.
Colloids Surf B Biointerfaces
January 2025
Institute of Cancer Therapeutics, University of Bradford, Bradford, Richmond Rd, Bradford BD7 1DP, United Kingdom. Electronic address:
Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer defined by the lack of three key receptors: estrogen, progesterone, and HER2. This lack of receptors makes TNBC difficult to treat with hormone therapy or drugs, and so it is characterised by a poor prognosis compared to other kinds of breast cancer. This study explores photoactive Poly(lactic-co-glycolic acid) (PLGA) nanoparticles as a potential therapeutic strategy for TNBC.
View Article and Find Full Text PDFMenstrual cycle effects on thermoregulation while exercising in the heat.
J Therm Biol
January 2025
School of Integrative Physiology and Athletic Training, University of Montana, 32 Campus Drive, Missoula, MT, 59812, USA. Electronic address:
Women may be challenged to maintain thermoregulation due to hormonal changes associated with the menstrual cycle. The purpose of this study was to assess the effect of the menstrual cycle phase on core temperature, hydration status, and perceived exertion while exercising under uncompensable heat gain. Eleven eumenorrheic women (24.
View Article and Find Full Text PDFIn Vitro Effect of Estrogen and Progesterone on Cytogenetic Profile of Uterine Leiomyomas.
Int J Mol Sci
December 2024
D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, 199034 St. Petersburg, Russia.
In the present study, we aimed to investigate intratumoral karyotype diversity as well as the estrogen/progesterone effect on the cytogenetic profile of uterine leiomyomas (ULs). A total of 15 UL samples obtained from 15 patients were cultured in the media supplemented with estrogen and/or progesterone and without adding hormones. Conventional cytogenetic analysis of culture samples revealed clonal chromosomal abnormalities in 11 out of 15 ULs.
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