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Meta-Analysis of MINIject vs. Two iStents as Standalone Treatment for Glaucoma with 24 Months of Follow-Up.
J Clin Med
December 2024
Swiss Visio Glaucoma Research Center, Montchoisi Clinic, 1006 Lausanne, Switzerland.
This study compares the long-term intraocular pressure (IOP)-lowering efficacy of standalone MINIject (iSTAR Medical, Belgium) suprachoroidal implantation and two iStent (Glaukos, CA, USA) trabecular bypass implantation using a systematic review and meta-analysis. Systematic review of standalone implantation of MINIject or iStent inject with at least 24 months of follow up. The mean and standard deviation of IOP and the number of IOP-lowering medications at baseline and at 24 months were extracted.
View Article and Find Full Text PDFDevelopment of self-healing hydrogels to support choroidal endothelial cell transplantation for the treatment of early age related macular degeneration.
Acta Biomater
December 2024
Institute for Vision Research, Carver College of Medicine; University of Iowa, Iowa City, IA; Department of Ophthalmology and Visual Sciences, Carver College of Medicine University of Iowa, Iowa City, IA. Electronic address:
In retinal diseases such as age-related macular degeneration (AMD) and choroideremia, a key pathophysiologic step is loss of endothelial cells of the choriocapillaris. Repopulation of choroidal vasculature early in the disease process may halt disease progression. Prior studies have shown that injection of donor cells in suspension results in significant cellular efflux and poor cell survival.
View Article and Find Full Text PDFOptical clearing with tartrazine enables deep transscleral imaging with optical coherence tomography.
J Biomed Opt
December 2024
Duke University Medical Center, Department of Ophthalmology, Durham, North Carolina, United States.
Significance: Imaging deep structures with optical coherence tomography (OCT) is difficult in highly scattering biological tissue, such as the sclera. There is a need to visualize the suprachoroidal space and choroid through the sclera to study suprachoroidal drug delivery.
Aim: We aim to develop optical methods to image through the highly scattering sclera with a custom-built OCT system to visualize the suprachoroidal space and drug delivery within.
Suprachoroidal Triamcinolone Acetonide for Noninfectious Uveitis: Real-World Impact on Clinical Outcomes.
Am J Ophthalmol
December 2024
From the Department of Ophthalmology & Vision Science, University of California (K.P., A.H., P.E.-N., G.Y., K.M.), Davis, Sacramento, California, USA. Electronic address:
Article Synopsis
- The study aimed to assess the effects of suprachoroidal triamcinolone acetonide (TA) injections on patients with noninfectious uveitis, focusing on key outcomes like central subfield thickness (CST) and visual acuity.
- Data was collected from 61 eyes of 51 patients over two years, revealing a significant reduction in CST from 437.61 microns to 348.17 microns within 6 weeks following treatment, along with an improvement in fluorescein angiography scores.
- Results showed that while some patients needed additional treatment for macular edema over time, 41.2% of those followed for 24 weeks did not require further interventions, and
Suprachoroidal Space in Rhegmatogenous Retinal Detachment Assessed with Optical Coherence Tomography: Implications for Potential Future Therapeutic Interventions.
Retina
November 2024
Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada.
Purpose: To comprehensively investigate the suprachoroidal space (SCS) in the context of rhegmatogenous retinal detachment (RRD) using swept-source optical coherence tomography (SS-OCT).
Methods: We conducted a post hoc analysis of 90 consecutive patients with a primary RRD. Baseline SS-OCT scans were graded for the presence and thickness of the suprachoroidal space.
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