The metabolic affects of anapriline, captopril, and clophelin were studied in the blood and liver homogenates ex vivo and in vitro in experiments on intact rats and rats with alloxan diabetes. Anapriline lowered the blood lactate content in rats with diabetes and intact rats, reduced the level of glycemia in animals with marked hyperglycemia. Captopril increased the blood insulin and lactate content in rats with diabetes and the content of pyruvate in vivo. The results of the study show that the use of clophelin and anaprilin in the treatment of patients with diabetes mellitus is most rational.
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