AI Article Synopsis
- Chromosomal analysis of two children with alveolar rhabdomyosarcoma showed distinct chromosomal translocations: t(1;5)(q32;q31) and t(1;22)(q21;q11.2).
- Both patients' peripheral blood lymphocytes exhibited the same chromosomal abnormalities as their tumor cells.
- The translocation t(1;22) was found to be a new mutation from the parents, while the t(1;5) translocation was inherited from the father, suggesting that these genetic changes may be linked to the development of the cancer.
Article Abstract
Chromosomal analysis of tumor tissue from two children with alveolar rhabdomyosarcoma revealed t(1;5)(q32;q31) and t(1;22)(q21;q11.2) in all metaphases examined, respectively. Peripheral blood lymphocytes carried the same cytogenetic abnormality as that of the tumor cells in both patients. Parental lymphocytes were karyotypically normal in the patient with t(1;22), indicating a de novo constitutional translocation, but t(1;5) was paternally inherited in the other patient. The presence of constitutional translocations in these two children might have contributed to the development of alveolar rhabdomyosarcoma.
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| http://dx.doi.org/10.1016/s0165-4608(98)00014-4 | DOI Listing |
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