Acute drug poisonings of the child is a major problem for health authorities all over the world, and are responsible for serious morbidity with mortality risks. The present retrospective study has involved 150 cases of drug poisoning observed in the Casablanca children's hospital over a period of 7 years. Most intoxication cases are accidental (84%), (mostly in children of 1 to 5 years old 74.6%), willful (11.3%), or iatrogenic (4.7%). Happening most often at home (95%) with a high frequency between 5 and 6 p.m. (24%) and 11 a 12 p.m. (13.3%), time of strong hunger. The large majority of drugs wer psychotropic agents (56%), principally diazepins (39%). Followed by oral contraceptive (8%), antihistaminics (8%), analgesics (7%), antibiotics (4%) and others (11%). Prevention is of high importance, and must be made effective on the wildest scale.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
N-acetylcysteine prevents cholinergic and non-cholinergic toxic effects induced by nerve agent poisoning in rats.
Toxicol Res (Camb)
February 2025
Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, India.
Objective: Organophosphorus Nerve Agent, VX [(O-Ethyl S-diisopropylaminomethyl) methylphosphonothioate] compound interferes with acetylcholine signaling by targeting the AChE enzyme. Studies suggest that in nerve agents poisoning, non-cholinergic effects are also responsible for damage in peripheral tissues including long term damage in brain. Present study reports cholinergic and non-cholinergic effects of VX poisoning and their prevention by use of N-acetylcysteine (NAC) in addition to conventional antidotes atropine sulphate and 2-PAM chloride as an antioxidant.
View Article and Find Full Text PDFEvaluation of acute substance abuse patients admitted to the ICU by different scoring system.
Toxicol Res (Camb)
February 2025
Department of Forensic Medicine and Clinical Toxicology, Champollion street, Faculty of Medicine, University of Alexandria, Alexandria, 21517, Egypt.
Drug abuse poisoning is a significant public health problem in many countries all over the world. The recent study aimed to assess the applicability of NEWS II and APACHE II scores as predictors of the ICU admission of acute intoxication by substance abuse. The study enrolled 98 patients admitted to the Alexandria Poison Center of the Main University Hospital (APC-AMUH) with a history of acute intoxication with substance abuse.
View Article and Find Full Text PDFRisk Prediction of Liver Injury in Pediatric Tuberculosis Treatment: Development of an Automated Machine Learning Model.
Drug Des Devel Ther
January 2025
Department of Pharmacy, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, 410004, People's Republic of China.
Purpose: Drug-induced liver injury (DILI) is one of the most common and serious adverse drug reactions related to first-line anti-tuberculosis drugs in pediatric tuberculosis patients. This study aims to develop an automatic machine learning (AutoML) model for predicting the risk of anti-tuberculosis drug-induced liver injury (ATB-DILI) in children.
Methods: A retrospective study was performed on the clinical data and therapeutic drug monitoring (TDM) results of children initially treated for tuberculosis at the affiliated Changsha Central Hospital of University of South China.
Spatial Accessibility Analysis of Snake Antivenom.
Int J Public Health
January 2025
School of Public Health, Hainan Medical University, Haikou, Hainan Province, China.
Objectives: To analyze the spatial accessibility of antivenom immunizing agents equipped hospitals in Hainan Province.
Methods: This paper analyzes the spatial accessibility of medical institutions equipped with different types of snake antivenom using network analysis and two-step mobile search method, and evaluates the service level and spatial accessibility of medical institutions equipped with different types of antivenom immunizing agents in Hainan Province from the perspectives of both supply and demand.
Results: The number of people in Hainan Province who need to spend more than 1 h to reach an antivenom, antivenom, antivenom, antivenom equipped hospital, and equipped with antivenom for all species of snakes in the country is approximately 856,000, 231,300, 3,071,000, 2,666,000 and 4,721,000 people, respectively.
Evaluation of the safety profile of amivantamab based on real-world evidence: a call to vigilance.
Expert Opin Drug Saf
January 2025
Department of Pharmacy, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, China.
Background: Amivantamab has been approved for EGFR exon 20 insertion-mutated non-small-cell lung cancer. The aim of this study was to perform an in-depth analysis of its safety profile.
Research Design And Methods: Safety reports were collected from the database of the Food and Drug Administration Adverse Event Reporting System from April 2021 to September 2023, and the reporting odds ratio (ROR) method was used to detect potential safety signals.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!