AI Article Synopsis
- T-cells play a crucial role in the immune defense against tumors caused by DNA viruses, supported by various research findings.
- The review highlights recent discoveries related to three key DNA viruses: human papillomavirus (linked to cervical cancer), human adenovirus (associated with lung infections in humans and tumors in rodents), and simian virus 40 (connected to certain rodent tumors and specific human cancers).
- Understanding these relationships helps in exploring potential therapeutic strategies for virus-induced cancers.
Article Abstract
An important role in the immune defense against deoxyribonucleic acid virus induced tumors is mediated by T-cells, as is evident from aetiological, animal model, and clinical data. In this review the most recent observations in this field are described for three prominent members of this family of viruses, namely human papillomavirus associated with human cervical cancer, human adenovirus associated with lung infections in humans and tumors in rodents, and simian virus 40 associated with rodent tumors and human mesothelioma, osteosarcoma and ependymoma.
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