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Evaluating the Effectiveness of Assisted Oocyte Activation in ICSI: Pairwise Meta-Analyses and Systematic Evidence Evaluation.
BJOG
January 2025
Obstetrics and Gynaecology Department, Ain Shams University, Cairo, Egypt.
Background: Artificial oocyte activation (AOA) is used to improve fertilisation rates in intracytoplasmic sperm injection (ICSI) cycles.
Objectives: To assess the effectiveness of AOA on fertilisation, embryo development, and clinical outcomes, including live birth.
Search Strategy: We searched PubMed, Cochrane, and Scopus from January 1990 to March 2024 using terms related to 'artificial oocyte activation' and 'ICSI.
The correlation between ANAs and pregnancy loss and their impact on IVF/ICSI-ET pregnancy outcomes in patients with recurrent pregnancy loss.
Int J Gynaecol Obstet
January 2025
Department of Reproductive Medicine, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Objective: To explore the correlation between antinuclear antibodies (ANAs) and pregnancy loss (PL), and to observe its impact on the pregnancy outcomes of in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) in recurrent PL (RPL) patients.
Methods: In this retrospective study, patients first seen at the hospital between January 2016 and December 2022 and who underwent two ANA tests within 4-6 weeks were included. After exclusion of confounding factors, patients were allocated to the non-pregnancy loss (non-PL), single-PL, or RPL group according to previous number of PLs, and the correlation between PL and ANAs was analyzed.
Methods and Efficacy of Processing Testicular Sperm Samples in Obstructive and Non-Obstructive Azoospermia: A Systematic Review.
J Mens Health
November 2024
The James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, MD.
Intracytoplasmic sperm injection (ICSI) is a cornerstone in managing male infertility, especially in obstructive azoospermia (OA) and non-obstructive azoospermia (NOA), necessitating sperm retrieval via testicular sperm extraction (TESE) or microdissection TESE (mTESE). However, the varied post-sperm extraction processing methods pose uncertainty regarding optimal approaches. To address this, a systematic review following preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) guidelines was conducted, identifying 16 relevant studies.
View Article and Find Full Text PDFCase report: Comprehensive evaluation and management of male infertility with complete AZFC microdeletion and undescended testicle.
Urol Case Rep
March 2025
Private Practice, Istanbul, Turkiye.
This case report presents a 31-year-old male patient with primary infertility, a unilaterally undescended testicle, and a complete AZFc microdeletion. Despite failed attempts at testicular sperm extraction, the patient underwent successful microscopic testicular sperm extraction and subsequent viable sperm extraction, leading to successful fertilization through intracytoplasmic sperm injection (ICSI). The report underscores the potential for successful ICSI in male infertility cases with complex genetic and reproductive issues, highlighting the importance of comprehensive genetic evaluation and individualized reproductive techniques in managing male infertility associated with undescended testicle and genetic anomalies.
View Article and Find Full Text PDFThe role of granulocyte-macrophage colony-stimulating factor in female assisted reproductive technology treatment: a systematic review and meta-analysis.
J Assist Reprod Genet
January 2025
Reproductive Medical Center, The Second Hospital of Jilin University, Changchun, 130000, China.
The objective of this study is to explore the impact of the use of granulocyte-macrophage colony-stimulating factor (GM-CSF) in female undergoing assisted reproductive technology (ART) on reproductive outcomes. A literature search was performed using electronic databases (PubMed, EMBASE, Web of Science, CNKI, Wanfang data, Geen Medical, and Cochrane Library). Risk ratio (RR), odds ratio (OR), and mean difference (MD) with 95% confidence intervals (CI) for various outcomes were presented.
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