Subcellular targeting of the cAMP-dependent protein kinase is achieved, in part, through association with A-kinase anchoring proteins (AKAPs). Recent evidence suggests that specific AKAPs direct the kinase to submembrane sites to facilitate phosphorylation and modulation of a variety of ion channels. A new membrane-anchored AKAP targets cAMP-dependent protein kinase to calcium channels and enhances their regulation in multiple cell types.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0959-4388(98)80057-3 | DOI Listing |
Publication Analysis
Top Keywords
camp-dependent protein
12
protein kinase
12
ion channels
8
a-kinase anchoring
8
anchoring proteins
8
regulation ion
4
channels camp-dependent
4
kinase
4
kinase a-kinase
4
proteins subcellular
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!