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Persistent microbial infections and idiopathic pulmonary fibrosis - an insight into pathogenesis.
Front Cell Infect Microbiol
January 2025
Center for Metabolic and Degenerative Diseases, The Brown Foundation Institute of Molecular Medicine for Prevention of Human Diseases, UTHealth-McGovern Medical School, Houston, TX, United States.
Interstitial lung disease (ILD) is characterized by chronic inflammation and scarring of the lungs, of which idiopathic pulmonary fibrosis (IPF) is the most devastating pathologic form. Idiopathic pulmonary fibrosis pathogenesis leads to loss of lung function and eventual death in 50% of patients, making it the leading cause of ILD-associated mortality worldwide. Persistent and subclinical microbial infections are implicated in the acute exacerbation of chronic lung diseases.
View Article and Find Full Text PDFMonte Carlo methods to assess biological response to radiation in peripheral organs and in critical organs near the target.
Rep Pract Oncol Radiother
December 2024
Department of Electroradiology, Poznan University of Medical Sciences, Poznan, Poland.
Background: The biological effects and clinical consequences of out-of-field radiation in peripheral organs can be difficult to determine, especially for low doses (0.1 Gy-1 Gy). In recent years, Monte Carlo (MC) methods have been proposed to more accurately predict nontarget doses.
View Article and Find Full Text PDFMolecular glue degrader for tumor treatment.
Front Oncol
December 2024
Department of Hematology, Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China.
Targeted Protein Degradation (TPD) represented by Proteolysis-Targeting Chimeras (PROTAC) is the frontier field in the research and development of antitumor therapy, in which oral drug HP518 Receives FDA Proceed Authorization for its IND Application for Prostate Cancer Treatment. Recently, molecular glue, functioning via degradation of the target protein is emerging as a promising modality for the development of therapeutic agents, while exhibits greater advantages over PROTAC, including improved efficiency, resistance-free properties, and the capacity to selectively target "undruggable" proteins. This marks a revolutionary advancement in the landscape of small molecule drugs.
View Article and Find Full Text PDFThe reverse water gas shift reaction (RWGS) mechanism study on the γ-MoC(100) surface.
RSC Adv
January 2025
Institute of Molecular Science, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University Taiyuan 030006 China
CO conversion and reuse technology are crucial for alleviating environmental stress and promoting carbon cycling. Reverse water gas shift (RWGS) reaction can transform inert CO into active CO. Molybdenum carbide (MoC) has shown good performance in the RWGS reaction, and different crystalline phases exhibit distinct catalytic behaviors.
View Article and Find Full Text PDFAn online national quality assessment survey of prostate MRI reading: interreader variability in prostate volume measurement and PI-RADS classification.
Eur J Radiol Open
June 2025
Institution of Molecular Medicine and Surgery (MMK), Karolinska Institutet, Stockholm, Sweden.
Background: High-quality assessment of prostate MRI is fundamental in both clinical practice and screening. There is a lack of national level data on variability in prostate volume measurement and PI-RADS assessment. Methods of quality assurance need to be developed.
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