AI Article Synopsis
- A 17-year-old male patient on Pyrimethamin therapy was discharged with instructions for ongoing monitoring but returned a month later with severe anemia.
- A suspicion of Pyrimethamin intoxication arose due to his noncompliance with treatment, confirmed by mass spectrometry revealing a drug concentration five times higher than the therapeutic range.
- Following rapid analysis and appropriate treatment, the patient's condition improved quickly, with a corresponding decrease in Pyrimethamin levels monitored throughout the treatment.
Article Abstract
A 17 years old male patient with Pyrimethamin therapy was released from our department by emphasising the necessity of continuous control. A month later the patient was accepted again with serious anaemia. Since the patient did not follow the instructions Pyrimethamin intoxication was presumed, but it had to be proved. At last the drug in the plasma was identified and quantified by mass spectrometry. The plasma concentration of Pyrimethamin was five times higher than the therapeutic level. The rapid analysis (4 hours after taking of blood) and adequate treatment resulted in rapid improvement with the concomitant decrease of plasma Pyrimethamin concentration. During clinical treatment the level of Pyrimethamin in the plasma was followed by mass spectrometry.
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