AI Article Synopsis
- FGF-2 regulates cell growth and differentiation through a dual receptor system involving heparan sulphate proteoglycans and FGFRs.
- The study is the first to map the distribution of FGF-2 and FGFRs in the seminiferous epithelium of adult males.
- Findings indicate that FGF-2 is present in spermatogonia, influencing their proliferation and differentiation via FGFR-1, FGFR-3, and FGFR-4, while FGFR-2 was not detected.
Article Abstract
Fibroblast growth factor 2 (FGF-2), which occurs in various isoforms both species and tissue specifically, regulates cell proliferation and differentiation via a dual receptor system consisting of heparan sulphate proteoglycans and receptor tyrosine kinases (FGFRs). This study demonstrates for the first time the distribution pattern of FGF-2 and the receptors FGFR 1-4 in the normal seminiferous epithelium of adult men. In western blot analyses, the polyclonal antibody, anti-FGF-2, shows two immunoreactive bands at 18 and 24 kDa. On paraffin sections, positive immunoreaction occurs within the cytoplasm of spermatogonia. The distribution pattern of the polyclonal anti-FGFR 1-4 antibodies is as follows: anti-FGFR-1 (one 68-kDa band) stains nuclei and cytoplasm of spermatogonia; anti-FGFR-3 (five bands at 68, 78, 105, 125 and 145 kDa) stains the nuclei of all germ cells except those of elongated spermatids; and anti-FGFR-4 (one 48-kDa band) stains the cytoplasm of primary pachytene spermatocytes. We were unable to demonstrate FGFR-2 immunoreactivity either in western blot analysis or on paraffin sections. This distribution pattern suggests that FGF-2 in spermatogonia is involved in the autocrine and paracrine regulation of the proliferation and differentiation of spermatogonia and spermatocytes via the receptors FGFR-1, FGFR-3 and FGFR-4.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s004180050265 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Epidemiological analysis of Leishmaniasis prevalence in Pakistan during 2016-2023.
Braz J Biol
January 2025
Near East University, Operational Research Center in Healthcare, Mersin, Turkey.
Leishmaniasis, caused by the Leishmania parasite, remains a persistent public health challenge in Pakistan. Despite control efforts, the disease prevalence continues to rise, particularly among pediatric populations. Understanding prevalence patterns and transmission dynamics is critical for effective control strategies.
View Article and Find Full Text PDFGender-Based Analysis of Injury Types and Risk Factors in Professional Tennis Players - Insights for Prevention: A Concise Review.
J Trauma Nurs
January 2025
Author Affiliations: NOVA Southeastern University, Kiran Patel College of Allopathic Medicine, Fort Lauderdale, Florida (Nunes Espat, Breeding, Nasef, and Amin); University of Hawaii, John A. Burns School of Medicine, Honolulu, Hawaii (Chin); Department of Surgery, Division of Trauma and Surgical Critical Care, Orlando Regional Medical Center, Orlando, Florida (Dr Elkbuli); and Department of Surgical Education, Orlando Regional Medical Center, Orlando, Florida (Dr Elkbuli).
Background: Tennis is a globally popular sport offering physical benefits but poses a high risk of injury due to its demands and prolonged gameplay. While injuries are common among professional players, detailed injury data for this group is limited.
Objective: This review aims to analyze trends in the incidence, type, region, and onset of injuries in professional tennis players, with particular attention to gender distribution, to improve guidelines and reduce injury impacts on performance and career longevity.
Spherical harmonics texture extraction for versatile analysis of biological objects.
PLoS Comput Biol
January 2025
European Molecular Biology Laboratory, Cell Biology and Biophysics Unit, Heidelberg, Germany.
The characterization of phenotypes in cells or organisms from microscopy data largely depends on differences in the spatial distribution of image intensity. Multiple methods exist for quantifying the intensity distribution - or image texture - across objects in natural images. However, many of these texture extraction methods do not directly adapt to 3D microscopy data.
View Article and Find Full Text PDFGenomic Analysis Reveals Racial and Age-Related Differences in the Somatic Landscape of Breast Cancer and the Association with Socioeconomic Factors.
Cancer Res
January 2025
University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Cancer genomics consortia have identified somatic drivers of breast cancer subtypes. However, these studies have predominantly included older, non-Black women, and the related socioeconomic status (SES) data is limited. Increased representation and depth of social data are crucial for understanding how health inequity is intertwined with somatic landscapes.
View Article and Find Full Text PDFAn ecological-evolutionary perspective on the genomic diversity and habitat preferences of the .
Microb Genom
January 2025
Department of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, OK, USA.
Members of the phylum inhabit a wide range of ecosystems including soils. We analysed the global patterns of distribution and habitat preferences of various lineages across major ecosystems (soil, engineered, host-associated, marine, non-marine saline and alkaline and terrestrial non-soil ecosystems) in 248 559 publicly available metagenomic datasets. Classes , , and were highly ubiquitous and showed a clear preference to soil over non-soil habitats, while classes and showed preferences to non-soil habitats.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!