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Novel Pharyngeal Oxygen Delivery Device Provides Superior Oxygenation during Simulated Cardiopulmonary Resuscitation.
Prehosp Disaster Med
December 2024
Baylor College of Medicine, Temple, TexasUSA.
Introduction: Passive oxygenation with non-rebreather face mask (NRFM) has been used during cardiac arrest as an alternative to positive pressure ventilation (PPV) with bag-valve-mask (BVM) to minimize chest compression disruptions. A dual-channel pharyngeal oxygen delivery device (PODD) was created to open obstructed upper airways and provide oxygen at the glottic opening. It was hypothesized for this study that the PODD can deliver oxygen as efficiently as BVM or NRFM and oropharyngeal airway (OPA) in a cardiopulmonary resuscitation (CPR) manikin model.
View Article and Find Full Text PDFChanges in hypoxic and hypercapnic ventilatory responses at high altitude measured using rebreathing methods.
J Appl Physiol (1985)
August 2024
Division of Biomedical Sciences, School of MedicineUniversity of California, Riverside, California, United States.
Ventilatory responses to hypoxia and hypercapnia play a vital role in maintaining gas exchange homeostasis and in adaptation to high-altitude environments. This study investigates the mechanisms underlying sensitization of hypoxic and hypercapnic ventilatory response (HVR and HCVR, respectively) in individuals acclimatized to moderate high altitude (3,800 m). Thirty-one participants underwent chemoreflex testing using the Duffin-modified rebreathing technique.
View Article and Find Full Text PDFThe ventilatory response to modified rebreathing is unchanged by hyperoxic severity: implications for the hyperoxic hyperventilation paradox.
J Appl Physiol (1985)
December 2023
School of Kinesiology, The University of Western Ontario, London, Ontario, Canada.
Normobaric hyperoxia stimulates ventilation (V̇e) in a time- and dose-dependent manner. Whether this occurs via an oxygen (O)-specific mechanism or secondary to carbon dioxide (CO) retention at the central chemoreceptors remains unclear. We measured the ventilatory response to hyperoxic CO rebreathing with O clamped at increasingly higher pressures.
View Article and Find Full Text PDFEvaluation of an adjusted MEWS (Modified Early Warning Score) for COVID-19 patients to identify risk of ICU admission or death in the Kingdom of Bahrain.
J Infect Public Health
November 2023
ABFM, Msc, DLSHTM Consultant Family Medicine, Epidemiology & Public Health Chief of Disease Control Section, Ministry of health Associate Prof. of Family and community Medicine, AGU.
Background: While most COVID-19 cases have uncomplicated infection, a small proportion has the potential to develop life-threatening disease, as such development of a prediction tool using patients baseline characteristics at the time of diagnosis should aid in early identification of high-risk groups and devise pertinent management. Hence, we set up this retrospective study to determine preadmission triaging tool to predict the development of severe COVID-19 in the Kingdom of Bahrain MATERIALS AND METHODS: A retrospective study was conducted from 1 September 2020 to 30 November 2020 with enrolment of all SARS-CoV-2 PCR-confirmed persons aged ≥ 14 years who attended Al-Shamil Field Hospital (SFH) in the Kingdom of Bahrain for triaging and assessment with recording of the following parameters: systolic blood pressure, heart rate, respiratory rate, temperature, the alert, verbal, pain, unresponsive neurological score, age, oxygen saturation, comorbidities, Body Mass Index (BMI), duration of symptoms and living with immunocompromised populations to develop our local adjusted MEWS as predictor for ICU admission & for consideration of suitable isolation at home. Follow up data of all patients was obtained from the electronic medical records system including CXR findings, treatments/medications received, need of oxygen supplements /intubation, needs of ICU care, and the outcome (death /discharged alive) IBM SPSS statistic version 21 program was used for data analysis.
View Article and Find Full Text PDFImpact of Blood Flow Restriction Exercise on Central Hemodynamics and Fluid Regulating Hormones.
Med Sci Sports Exerc
February 2024
Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, CANADA.
Purpose: The purpose of this study is to characterize both the efficacy of altered restriction pressures and consequences of optimized blood flow restriction (BFR) for altering the cardiovascular and fluid regulating response in humans.
Methods: This work comprised a series of related trials. Phase 1: during semi-recumbent cycling (5 min, 60 W) with BFR at 0%, 50%, 75%, 100%, and 125% of participants' lowest arterial occlusion pressure (LOP) echocardiographic images were collected alongside continuous heart rate (HR) and blood pressure (BP).
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