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Background: The effects of ionizing radiation (IR) involve a highly orchestrated series of events in cells, including DNA damage and repair, cell death, and changes in the level of proliferation associated with the stage of the cell cycle. A large number of existing studies in literature have examined the activity of genes and their regulators in mammalian cells in response to high doses of ionizing radiation. Although there are many studies, the research in effect of low doses of ionizing radiation remains limited.

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Simple User-Friendly Reaction Format.

Mol Inform

January 2025

Department of Biosystems Science and Engineering, ETH Zurich, Klingelbergstrasse 48, 4056, Basel, Switzerland.

Utilizing the growing wealth of chemical reaction data can boost synthesis planning and increase success rates. Yet, the effectiveness of machine learning tools for retrosynthesis planning and forward reaction prediction relies on accessible, well-curated data presented in a structured format. Although some public and licensed reaction databases exist, they often lack essential information about reaction conditions.

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Objective: Thyroid dysfunction represents common disorder occurring very frequently among women of reproductive age, including pregnancy. The aim of this literature review was to determine in which way thyroid function during pregnancy is associated with GDM.

Design: We conducted review of the literature following the basic principles of literature search.

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Concept-formation and deep disagreements in theoretical and practical reasoning.

Synthese

January 2025

Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX UK.

This paper explores the idea that deep disagreements essentially involve disputes about what counts as good reasoning, whether it is theoretical or practical reasoning. My central claim is that deep disagreements involve radically different paradigms of some principle or notion that is constitutively basic to reasoning-I refer to these as "basic concepts". To defend this claim, I show how we can understand deep disagreements by accepting the indeterminacy of concept-formation: concepts are not set in stone but are responsive to human needs, and differences in individuating and ordering concepts lead to clashes in paradigms of reasoning.

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