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Hyperhomocysteinemia-induced VCID results in visual deficits, reduced neuroinflammation and vascular alterations in the retina.
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Stark Neurosciences Research Institute, Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Over recent years, the retina has been increasingly investigated as a potential biomarker for dementia. A number of studies have looked at the effect of Alzheimer's disease (AD) pathology on the retina and the associations of AD with visual deficits. However, while OCT-A has been explored as a biomarker of cerebral small vessel disease (cSVD), studies identifying the specific retinal changes and mechanisms associated with cSVD are lacking.
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Gastroenterology, University of Washington School of Medicine, Seattle, USA.
Current cancer screening methods are effective for detecting early stage cancers and even preventing some cancers, but their effectiveness has only been demonstrated for a handful of cancers, and for many cancers, there are no screening tests clinically available. In addition, the majority of the screening methods are not ideal, resulting in suboptimal compliance and the occurrence of preventable cancers. A screening test that is convenient, safe, accurate and that can screen for multiple cancers is an ideal screening test that would address many of the shortcomings of the current tests.
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College of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar 161006 China. Electronic address:
A new colorimetric fluorescent sensor QPEBT was developed by merging the N,N-di(2-picolyl)ethane-1,2-diamine and 2,2'-bithiophene moieties into the quinolimide backbone. QPEBT could sensitively detect Zn through the remarkable fluorescence enhancement with distinct color changes from light orange to pink in visible light and from ginger to orange-yellow in 365 nm UV irradiation. The 1:1 stoichiometry between QPEBT and Zn was verified by the spectra titrations, Job's and HRMS analyses, and theoretical calculations.
View Article and Find Full Text PDFEnhanced chemiluminescence of luminol via InS/MXene composite as a novel Co-reactant accelerator for UV-filter Benzophenone-3 determination.
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Shenzhen Key Laboratory of Organic Pollution Prevention and Control, School of Biomedical Engineering, Harbin Institute of Technology Shenzhen, Shenzhen, 518055, China. Electronic address:
In this study, a novel In₂S₃/MXene composite was developed as a co-reactant accelerator to enhance the chemiluminescence (CL) performance of the classical luminol-H₂O₂ system. The In₂S₃ and MXene heterojunction catalyzed the CL reaction through synergistic effect, facilitating the generation of reactive oxygen species and increasing CL intensities. This enhanced system was applied for the first time to detect an ultraviolet (UV) filter-benzophenone-3 (BP-3) by leveraging its light absorption property.
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14th European Reference Network in Neuromuscular Disorders (EURO-NMD), Scientific Laboratory of Molecular Genetics, Riga Stradins University, Riga, Latvia.
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