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Similar Publications

Efficacy and safety of azathioprine in patients with Cronkhite-Canada syndrome: a case series from Peking Union Medical College Hospital.

BMC Pharmacol Toxicol

December 2024

Department of Gastroenterology, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, China.

Background: Cronkhite-Canada syndrome (CCS) is a rare non-hereditary chronic inflammatory disease characteristic of gastrointestinal polyps and ectodermal abnormalities. Corticosteroid therapy is the mainstay medication for CCS. Few studies indicated immunosuppressants might be the choices for patients with steroid refractory, steroid dependent or intolerant.

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Article Synopsis
  • Cronkhite-Canada syndrome (CCS) is a rare, nonhereditary condition characterized by gastrointestinal polyps, ectodermal changes, and symptoms such as hair loss, skin pigmentation, and malnutrition, predominantly affecting middle-aged and older males.* -
  • The case study involves a 72-year-old female who experienced severe gastrointestinal issues, which led to the discovery of multiple polyps through endoscopic examinations after her treatment for intestinal obstruction.* -
  • Following a comprehensive treatment plan that included medications and nutritional support, the patient showed significant improvement in symptoms, with reduced diarrhea and a notable decrease in the number and size of polyps upon follow-up examination.*
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Article Synopsis
  • Cronkhite-Canada syndrome (CCS) is a rare condition in children that often goes misdiagnosed due to its complex symptoms.
  • A case study of a 13-year-old boy highlighted symptoms like persistent diarrhea, vomiting, weight loss, alopecia, and skin changes, with lab tests revealing specific autoimmune indicators.
  • The study concludes that thorough assessments, including endoscopic and histological evaluations, are crucial for diagnosing CCS, and treatment with steroids like prednisone can significantly improve symptoms.
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Cronkhite-Canada syndrome complicated with pulmonary embolism: A case report.

World J Clin Cases

July 2024

Department of Gastroenterology, The First Affiliated Hospital of Shihezi University, Shihezi 832008, Xinjiang Uygur Autonomous Region, China.

Article Synopsis
  • Cronkhite-Canada syndrome (CCS) is a rare condition characterized by gastrointestinal polyps, skin changes, and a range of gastrointestinal symptoms, with a notable risk for thromboembolic complications.
  • A case study of a 46-year-old male with CCS revealed significant health issues including mucus and bloody stool, skin pigmentation, and pulmonary embolism, leading to a complex treatment plan that improved his symptoms.
  • This case marks the first report of CCS complicated by pulmonary embolism in China, highlighting the need for increased awareness and preventive measures for venous thromboembolism risk in CCS patients.
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A case of membranous nephropathy complicated by Cronkhite-Canada syndrome successfully treated with mizoribine.

CEN Case Rep

July 2024

Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-Cho, Okayama, 700-8558, Japan.

Cronkhite-Canada syndrome (CCS) is a non-hereditary disorder characterized by non-neoplastic hamartomatous gastrointestinal polyposis, hair loss, nail atrophy, hyperpigmentation, and diarrhea. While the relationship between CCS and nephritis remains unclear, seven cases of nephritis complicated by CCS have been reported to date, all of which were membranous nephropathy (MN). A 57-year-old man presented with taste disturbance, hair loss, nail plate atrophy, skin pigmentation, and frequent diarrhea.

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