Chemical mapping of co-existing RNA structures. | LitMetric

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Chemical mapping of co-existing RNA structures. | LitMetric

Chemical mapping of co-existing RNA structures.

A R Schröder T Baumstark D Riesner

Nucleic Acids Res

Institut für Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, D-40225 Düsseldorf, Germany.

Published: July 1998

In many cases RNA can assume co-existing or meta-stable structures preventing structure determination by chemical mapping. A novel method is described, by which RNA is modified with dimethyl sulphate without shifting the distribution of different structures. The different structures are then separated in native gel electrophoresis, and structure determination by primer extension can be carried out separately for each structure.

Download full-text PDF	Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC147709	PMC
http://dx.doi.org/10.1093/nar/26.14.3449	DOI Listing

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