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Abnormal methylation of Mill1 gene regulates osteogenic differentiation involved in various phenotypes of skeletal fluorosis in rats and methionine intervention.
Ecotoxicol Environ Saf
December 2024
School of Public Health, Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang 561113, China. Electronic address:
Excessive fluoride intake can lead to skeletal fluorosis. Nutritional differences in the same fluoride-exposed environment result in osteosclerosis, osteoporosis, and osteomalacia. DNA methylation has been found to be involved in skeletal fluorosis and is influenced by environment and nutrition.
View Article and Find Full Text PDFSkeletal fluorosis: an uncommon cause, yet a rescue treatment?
Osteoporos Int
October 2024
University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Article Synopsis
- Skeletal fluorosis (SF) arises from long-term fluoride exposure, leading to brittle bones and fractures, with no established treatment except for avoiding fluoride sources.
- A case study of a 50-year-old woman showed she suffered from frequent fractures and elevated fluoride levels due to huffing a keyboard cleaner containing fluoride.
- After stopping fluoride exposure, the patient was treated with abaloparatide, a hormone to enhance bone remodeling, which resulted in decreased fluoride levels and some reduction in bone density, indicating potential benefits in managing SF.
Frequency of superscan on bone scintigraphy: A systematic review.
Clin Physiol Funct Imaging
September 2023
Department of Nuclear Medicine, Aalborg University Hospital, Aalborg, Denmark.
Introduction: Bone scintigraphy (BS) is an important tool for detecting bone metastasis. BS with diffuse increased skeletal radioisotope uptake with absent or faint urinary tract and soft tissue activity is defined as a superscan. In this review, we investigate the different etiologies causing superscan and the reported frequency of superscan among different disease entities.
View Article and Find Full Text PDFSkeletal and extraskeletal disorders of biomineralization.
Nat Rev Endocrinol
August 2022
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
The physiological process of biomineralization is complex and deviation from it leads to a variety of diseases. Progress in the past 10 years has enhanced understanding of the genetic, molecular and cellular pathophysiology underlying these disorders; sometimes, this knowledge has both facilitated restoration of health and clarified the very nature of biomineralization as it occurs in humans. In this Review, we consider the principal regulators of mineralization and crystallization, and how dysregulation of these processes can lead to human disease.
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