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Melatonin promotes the proliferation and differentiation of antler chondrocytes via RUNX2 dependent on the interaction between NOTCH1 and SHH signaling pathways.
Cell Biol Int
December 2024
College of Veterinary Medicine, Jilin University, Changchun, China.
Melatonin (MT), an endogenous hormone secreted by pineal gland, has the sedative, anti-inflammatory and antioxidant functions. However, there are few studies on whether MT affects the proliferation and differentiation of antler chondrocytes. The present study investigated the influences of MT on the proliferation and differentiation of antler chondrocytes, explored its regulation on runt-related transcription factor 2 (RUNX2), NOTCH1 and sonic hedgehog (SHH) signaling, and elucidated their interplays.
View Article and Find Full Text PDFFluctuations of antimüllerian hormone, ovarian follicular reserve, and antioxidant status throughout the estrous cycle in aged mares.
Open Vet J
November 2024
Theriogenology Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
Background: Senility influences fertility in women and companion animals, especially horses.
Aim: This study aimed to investigate the effect of aging in horses on the daily changes in the dominant follicle (DF) dynamics and hemodynamics, antimüllerian hormone (AMH), enzymes, antioxidants, and ovarian hormones during the estrous cycle.
Methods: Ovaries of old mares ( = 5, age >20 years) and young native mares ( = 6, age <10 years) were scanned during 6 different estrous cycles from March 2022 to August 2023 with Doppler ultrasound.
Hematological and biochemical parameters in the blood of working Belgian Shepherd dogs: An age-related study.
Open Vet J
November 2024
Department for Clinical Sciences, University of Sarajevo-Veterinary Faculty, Sarajevo, Bosnia and Herzegovina.
Background: Age-related changes in physiological parameters are crucial in understanding the health and performance of working dogs, particularly those in demanding roles such as military and law enforcement. However, limited research exists on how aging affects the hematological and biochemical health of these dogs.
Aim: This study aims to characterize age-related variations in hematological and biochemical parameters in working Belgian Shepherd dogs to provide insights that could inform health management strategies for these animals.
Prediction of primary biliary cholangitis among health check-up population with anti-mitochondrial M2 antibody positive.
Clin Mol Hepatol
December 2024
Department of Clinical Laboratory, State key Laboratory of Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Background: Anti-mitochondrial M2 antibody (AMA-M2) is a specific marker for primary biliary cholangitis (PBC) and it could be also presented in non-PBC individuals.
Methods: A total of 72173 Chinese health check-up individuals tested AMA-M2, of which non-PBC AMA-M2 positive individuals were performed follow-up. Baseline data of both clinical characteristics and laboratory examinations were collected in all AMA-M2-positive individuals.
Evaluation of calcium, phosphorus and some biochemical parameters in dogs with open and closed cervix pyometra.
Pol J Vet Sci
June 2024
İstanbul University-Cerrahpaşa, Department of Industrial Engineering, Faculty of Engineering, Istanbul, 34320, Türkiye.
The aim of this study was to evaluate the changes in calcium, phosphorus and some biochemical parameters in dogs with open and closed cervix pyometra, which was then compared with a control group. A total of 62 bitches of age group 5-10 years old irrespective of breed were enrolled into the study. Control group consisted of 22 bitches which were clinically healthy and in luteal phase of the estrus cycle.
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