Humeral, tibial and cutaneous localizations of Histoplasma capsulatum var. duboisii were observed on a 6 year old boy. The diagnosis was made possible by anatomo-pathological and mycological examinations. Treatment with terbinafine was administrated for 4 months. The boy recovered without after-effects in the tibial localization, but did suffer after-effects in the humeral localization.
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Infection
January 2025
Department of Medical Microbiology and Immunology, Faculty of Medicine, Gulu University, Gulu, Uganda.
Purpose: Pancytopenia in the setting of disseminated histoplasmosis is sparsely described in the literature. We investigated the underlying mechanisms of pancytopenia in disseminated histoplasmosis and highlighted clinical outcomes.
Methods: We conducted a scoping review of cases and series on disseminated histoplasmosis presenting with pancytopenia published between 2001 and 2024.
Med Mycol
December 2024
UR 3738 - CICLY - Equipe Inflammation et immunité de l'épithélium respiratoire, Faculté de Médecine Lyon-Sud Charles Mérieux, Université Claude Bernard Lyon 1, Lyon, France.
Cryptococcus neoformans/gattii and Histoplasma capsulatum var. capsulatum may present atypical histopathological features inducing diagnostic errors. We aimed to estimate the frequency of these atypical features on formalin-fixed tissue samples (FT) and to assess the relevance of an integrated histomolecular diagnosis using specific Histoplasma capsulatum PCR and panfungal PCR followed by Sanger sequencing and/or targeted-massive parallel sequencing (MPS).
View Article and Find Full Text PDFFront Med (Lausanne)
December 2024
St Pauls Eye Clinic, Liverpool University Hospitals NHS Foundation Trust, Liverpool, United Kingdom.
We report a rare case of a rapidly growing and large conjunctival histoplasmosis lesion in an immunosuppressed West African woman in her 80s, affecting her only eye. The patient had undergone a renal transplant and was on immunosuppressive medications. Additionally, she had previously been treated for presumed systemic histoplasmosis with itraconazole more than 5 years ago.
View Article and Find Full Text PDFCureus
November 2024
Department of Dermatology, University of Nebraska Medical Center, Omaha, USA.
is a dimorphic fungus that causes pulmonary, disseminated, or, rarely, primary cutaneous disease. Primary cutaneous histoplasmosis presents with non-specific skin lesions, which can lead to poor patient outcomes due to diagnostic challenges and delays in diagnosis. A 62-year-old male on immunosuppressive medications for lupus nephritis presented to the emergency department with 24 hours of altered mental status.
View Article and Find Full Text PDFInfect Dis Clin North Am
December 2024
Department of Medicine, Division of Infectious Disease, Johns Hopkins University School of Medicine, Boston, MA, USA; Division of Infectious Diseases, Transplant and Oncology Infectious Diseases, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.
This review provides an update of histoplasmosis, covering the changing epidemiology, pathogenesis, disease manifestations, diagnostic strategies, and management considerations for immunocompetent and immunocompromised populations.
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