Thorascopic harvesting of the internal mammary artery for supercharging the rectus abdominis pedicled flap for breast reconstruction is presented. The procedure was carried on a woman who had previously undergone a mastectomy and who was obese and a diabetic. The patient underwent a "high" flap delay 2 weeks earlier. At the time of operative transfer and setting, the flap's vascularity was found to be compromised. Instead of turbocharging the deep inferior epigastric pedicle to the irradiated axillary vessels, it was possible to harvest and utilize the internal mammary artery without rib resection for the supercharging, thus saving the flap and reconstruction. The technical aspects, and possible advantages and disadvantages of such a procedure are discussed.
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http://dx.doi.org/10.1097/00000637-199806000-00015 | DOI Listing |
Chin J Cancer Res
January 2025
Big Data and Artificial Intelligence Laboratory, Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, China.
Objective: Early predicting response before neoadjuvant chemotherapy (NAC) is crucial for personalized treatment plans for locally advanced breast cancer patients. We aim to develop a multi-task model using multiscale whole slide images (WSIs) features to predict the response to breast cancer NAC more finely.
Methods: This work collected 1,670 whole slide images for training and validation sets, internal testing sets, external testing sets, and prospective testing sets of the weakly-supervised deep learning-based multi-task model (DLMM) in predicting treatment response and pCR to NAC.
Front Microbiol
February 2025
Key Laboratory of Livestock and Poultry Multi-omics, Ministry of Agriculture and Rural Affairs, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China.
The gut microbiota plays a crucial role in the growth performance, health status, and welfare of pigs. Breast milk is a key factor in the colonization of gut microbiota and the overall health of newborn piglets. With advancements in breeding technology, formula milk has been widely adopted as a substitute for breast milk.
View Article and Find Full Text PDFDiagnostics (Basel)
February 2025
School of Informatics, University of Edinburgh, Edinburgh EH8 9YL, UK.
Early and accurate detection of breast cancer is crucial for improving treatment outcomes and survival rates. To achieve this, innovative imaging technologies such as microwave radiometry (MWR)-which measures internal tissue temperature-combined with advanced diagnostic methods like deep learning are essential. To address this need, we propose a hierarchical self-contrastive model for analyzing MWR data, called Joint-MWR (J-MWR).
View Article and Find Full Text PDFCancers (Basel)
February 2025
Department of Pharmaceutical Chemistry, Institute of Pharmacy, Nirma University, Ahmedabad 382481, Gujarat, India.
This study explores the design of substituted tetrahydroquinoline (THQ) derivatives and their synthesis as possible inhibitors of mTOR inhibitors for targeted cancer therapy. Inspired by the structural characteristics of known mTOR inhibitors, eight novel derivatives were synthesized, characterized using mass spectroscopy, H, and C NMR, and evaluated for anticancer activity. Computational studies, including molecular docking and molecular dynamics (MD) simulations, highlighted the derivative's strong binding interaction and stability within the mTOR active site.
View Article and Find Full Text PDFBMC Cancer
March 2025
Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
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