AI Article Synopsis
- The study examined receptor activity of peripheral T cells in 67 healthy individuals compared to 29 patients with progressive hearing loss and 7 with sudden hearing loss of unknown cause.
- Significant differences were found in the "active" T-cell subset during TEa tests, indicating altered immune responses in hearing loss patients (p < 0.001).
- After starting ubiquitin therapy, normalization of T cell function was observed, suggesting potential therapeutic benefits.
Article Abstract
Receptors activity of peripheral T cells for sheep erythrocytes was analyzed in 67 healthy individuals and in the 29 patients with progressive, bilateral hearing loss and in 7 patients with sudden deafness on unknown etiology. The ability of T lymphocytes to form non-immune complete and incomplete rosettes in TEt and TEa tests was evaluated before and at the beginning of ubiquitine therapy. The mean values of rosette forming cells (RFC) in percentage and absolute numbers and the statistical analysis were presented. It was found that the receptor activity of T lymphocytes in TEt test was not significant different from the results of healthy control group. On the other hand highly significant differences were observed (p < 0.001) in subset of "active" T-cells determined in TEa rosette test. The relative coefficient of receptor activity of lymphocytes (CRAL) calculated for complete TEa rosettes was high different (p < 0.0008). Normalization of the results of TE rosette tests after first period of ubiquitin biotherapy was observed.
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