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Enhancing protective immunity against SARS-CoV-2 with a self-amplifying RNA lipid nanoparticle vaccine.
J Control Release
December 2024
School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, Guangdong 511442, China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, Guangdong 510006, China; Guangdong Provincial Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou, Guangdong 510006, China; Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou, Guangdong 510006, China. Electronic address:
RNA-based vaccines against SARS-CoV-2 have demonstrated promising protective immunity against the global COVID-19 epidemic. Enhancing the intensity and duration of mRNA antigen expression is anticipated to markedly boost antiviral immune responses. Self-amplifying RNA (saRNA) represents a next-generation platform for RNA-based vaccines, amplifying transcripts in situ to augment the expression of encoded immunogens.
View Article and Find Full Text PDFThe capicua-ataxin-1-like complex regulates Notch-driven marginal zone B cell development and sepsis progression.
Nat Commun
December 2024
Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, Republic of Korea.
Article Synopsis
- Follicular B (FOB) and marginal zone B (MZB) cells are essential for immune responses, but MZB cells can worsen endotoxic shock by producing interleukin-6.
- The study finds that the transcription factors capicua (CIC) and ataxin-1-like (ATXN1L) are crucial for the development of both FOB and MZB cells, with CIC deficiency reducing both populations while ATXN1L deficiency primarily impacts MZB cells.
- CIC deficiency disrupts B cell receptor signaling in FOB cells, and both deficiencies impair Notch signaling in MZB cells, with increased ETV4 levels preventing the development of MZB cells; deleting E
IL-33 protects from recurrent infection by restoration of humoral immunity.
bioRxiv
November 2024
Department of Medicine, Division of Infectious Diseases and International Health, Charlottesville, Virginia, USA.
Article Synopsis
- * IL-33 levels at diagnosis can predict the likelihood of CDI recurrence, leading researchers to explore how IL-33 contributes to the production of antibodies that fight the infection.
- * In a mouse model, it was found that IL-33 is essential for generating antibodies against TcdB with the help of specific immune cells, highlighting its importance in creating protection against future CDI infections through humoral immunity.
Factors Predicting COVID-19 Vaccine Effectiveness and Longevity of Humoral Immune Responses.
Vaccines (Basel)
November 2024
Infection Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
The COVID-19 pandemic, caused by SARS-CoV-2, prompted global efforts to develop vaccines to control the disease. Various vaccines, including mRNA (BNT162b2, mRNA-1273), adenoviral vector (ChAdOx1, Ad26.COV2.
View Article and Find Full Text PDFRescue immune tolerance induction with a recombinant factor Fc-fused VIII: prospective ReITIrate study of clinical, humoral and cellular immune responses.
Ther Adv Hematol
November 2024
Sobi, Swedish Orphan Biovitrum AB, SE-112 76, Sweden.
Background: Immune tolerance induction (ITI) is the gold standard for inhibitor eradication to restore the clinical efficacy of factor replacement therapy in haemophilia. However, as ITI often requires frequent administration over extended periods, it can be considered burdensome for patients and healthcare resources. Therefore, there is a need to optimise ITI treatment, particularly in patients who failed previous ITI attempts.
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