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Multi-diagnostic chest-worn patch to detect obstructive sleep apnea and cardiac arrhythmias.
J Clin Sleep Med
January 2025
Division of Sleep Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Study Objectives: Evaluate the performance of the SANSA device to simultaneously assess obstructive sleep apnea (OSA) and cardiac arrhythmias.
Methods: Participants suspected or known to have OSA underwent polysomnography (PSG) while wearing SANSA. SANSA's algorithm was trained using 86 records and tested on 67 to evaluate training bias.
Blockade of neddylation through targeted inhibition of DCN1 alleviates renal fibrosis.
Clin Sci (Lond)
January 2025
Zhengzhou University First Affiliated Hospital, Zhengzhou, China.
Neddylation is a process of attaching neuronal precursor cell-expressed developmentally downregulated protein 8 (NEDD8) to substrates for the protein function modulation via enzymatic cascades involving NEDD8-activating enzyme (E1), NEDD8-conjugating enzyme (E2), and NEDD8 ligase (E3). Defective in cullin neddylation 1 (DCN1) serves as a co-E3 ligase, that can simultaneously bind E2 UBE2M and cullin proteins to stabilize the catalytic center of the Cullin-Ring E3 ligase (CRL) complex, thereby promoting cullin neddylation. Neddylation is reported to be activated in diverse human diseases, and inhibition of protein neddylation has been regarded as a promising anticancer therapy.
View Article and Find Full Text PDFA New, Easy-to-Learn, Fear-Free Method to Stop Purring During Cardiac Auscultation in Cats.
Animals (Basel)
January 2025
Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CM Utrecht, The Netherlands.
Background: Purring in cats can interfere with cardiac auscultation. If the produced noise is loud enough, purring makes it impossible to perform a meaningful auscultation as it is much louder than heart sounds and murmurs. Our study introduced and tested a new, simple, fear-free, cat-friendly method to stop purring during auscultation.
View Article and Find Full Text PDFVisual System Inspired Algorithm for Enhanced Visibility in Coronary Angiograms (VIAEVCA).
Biomimetics (Basel)
January 2025
Nuclear Cardiology Unit and CCT Service, Meir Medical Center, Kfar-Saba 95847, Israel.
Numerous efforts have been invested in previous algorithms to expose and enhance blood vessel (BV) visibility derived from clinical coronary angiography (CAG) procedures, such as noise reduction, segmentation, and background subtraction. Yet, the visibility of the BVs and their luminal content, particularly the small ones, is still limited. We propose a novel visibility enhancement algorithm, whose main body is inspired by a line completion mechanism of the visual system, i.
View Article and Find Full Text PDFReview of simultaneous treatment with intradetrusor onabotulinumtoxinA injections during transurethral prostate surgery for men with bladder outlet obstruction and overactive bladder.
Tzu Chi Med J
October 2024
Department of Urology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan.
Bladder outlet obstruction (BOO) is common in males with benign prostate enlargement (BPE) and often presents with different lower urinary tract symptoms. Overactive bladder (OAB) has been reported to be related to BOO, although it can also be idiopathic. The storage symptoms of BOO are often similar to those of OAB.
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