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Sexual Health Advocacy for Guys (SHAG): a randomized trial of the impact of a text-messaging program on HIV incidence and STI testing among a national sample of sexual minority cisgender adolescent and young adult men.
Trials
January 2025
Department of Community and Behavioral Health, Colorado School of Public Health, Denver, CO, USA.
Background: Disparities in sexually transmitted infections (STI) including human immunodeficiency virus (HIV) among sexual minority boys and young men are substantial. Effective HIV and STI prevention programs that include access to pre-exposure prophylaxis (PrEP) medication do not consistently include younger sexual minority men. Text-messaging programs for HIV prevention have been associated with increases in HIV testing among sexual minority adolescent boys, but these programs have not incorporated a focus on PrEP or STIs beyond HIV.
View Article and Find Full Text PDFRubber band ligation or shaobei injection for the endoscopic treatment of symptomatic hemorrhoids? A retrospective study.
Surg Endosc
January 2025
Department of General Surgery (Endoscopic Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, No. 26 Yuancun Erheng Road, Tianhe, Guangzhou, 510655, Guangdong, China.
Background: It is unknown whether Shaobei injection is superior to band ligation for endoscopic symptomatic hemorrhoid treatment. We compared the clinical efficacy, safety, and health economics of the two techniques.
Aims: This study aims to compare the efficacy, safety and health economics of endoscopic injection of Shaobei and endoscopic ligation in the treatment of grade I-IV symptomatic hemorrhoids.
Prediction of checkpoint inhibitor immunotherapy efficacy for cancer using routine blood tests and clinical data.
Nat Med
January 2025
Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Predicting whether a patient with cancer will benefit from immune checkpoint inhibitors (ICIs) without resorting to advanced genomic or immunologic assays is an important clinical need. To address this, we developed and evaluated SCORPIO, a machine learning system that utilizes routine blood tests (complete blood count and comprehensive metabolic profile) alongside clinical characteristics from 9,745 ICI-treated patients across 21 cancer types. SCORPIO was trained on data from 1,628 patients across 17 cancer types from Memorial Sloan Kettering Cancer Center.
View Article and Find Full Text PDFHeptamethine cyanine-based polymeric nanoparticles for photothermal therapy in HCT116 human colon cancer model.
Sci Rep
January 2025
School of Chemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, 30000, Thailand.
In this work, we synthesize a quinoline-based heptamethine cyanine, QuCy7, with sulfonate groups to enhance water solubility. This dye demonstrates exceptional near-infrared absorption beyond 750 nm, accompanied by photothermal properties but low photostability. Encapsulating QyCy7 with polyethylene glycol to form nanopolymer, QuCy7@mPEG NPs, addresses the issue of its photoinstability.
View Article and Find Full Text PDFStability of refractive outcomes after hyperopic LASIK with and without Mitomycin C application: a randomized controlled trial.
Sci Rep
January 2025
Department of Ophthalmology, Medical Faculty, University Hospital Düsseldorf, Heinrich Heine University, Moorenstraße 5, 40225, Dusseldorf, Germany.
To assess the efficacy, safety, and stability of refractive outcomes in hyperopic Laser-Assisted in Situ Keratomileusis (LASIK) with and without the application of Mitomycin C (MMC). This randomized, parallel group, controlled multicenter trial included 140 hyperopic eyes. The participants were randomly assigned to two groups: one receiving LASIK with mitomycin C (MMC) (n = 70) and the other receiving LASIK without MMC (n = 70).
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