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An innovative ear transplantation for vascularized composite allotransplantation research in porcine model.
Sci Rep
December 2024
Pharmacology Research Group, Universidad del Valle, Colombia, Cali, 760043.
Vascularized composite allotransplantation (VCA) represents a clinical challenge for transplant therapy, as it involves different tissues with unique immunogenicity. Even when receiving immunosuppressive therapy, they are more vulnerable to severe hypoxia, microvascular damage, and ultimately the rejection or chronic graft dysfunction after transplantation. This study aimed to develop a surgical protocol for VCA of the ear in a porcine biomodel in the absence of immunosuppression, maintaining the in vitro co-culture of the allograft and assessing their relationship with allograft survival.
View Article and Find Full Text PDFFatal Hyperacute Liver Failure due to Varicella Zoster Virus Immediately After Living-Donor Liver Transplantation: A Case Report and Review of the Literature.
Pediatr Transplant
November 2024
Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Article Synopsis
- A case study is presented of a patient who developed fatal hyperacute liver failure from varicella zoster virus after a liver transplant, marking the first report of such an occurrence in liver transplant patients.
- Despite being positive for the virus, the patient was unvaccinated and undergoing immunosuppression, leading to quick deterioration of liver function within days post-surgery.
- The study highlights the difficulty in diagnosing hyperacute liver failure due to the absence of skin lesions and rapid progression of the disease, which has only been reported in a few other solid organ transplant cases.
Acute Onset of Impaired Consciousness.
Dtsch Arztebl Int
July 2024
Emergency Department, Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich; Department of Medicine III, Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich; Interdisciplinary Emergency Department, University Medical Center Regensburg, Regensburg; Department of Neurology, University Medical Center Freiburg, Freiburg; Kinderklinik und Kinderpoliklinik im Dr von Hauner Children's Hospital, Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich; Department of Neurology, Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich.
Article Synopsis
- Patients with sudden impaired consciousness have a high mortality rate, with 10% not surviving, and multiple underlying causes are often found.
- Impairment is categorized into quantitative (reduced wakefulness) and qualitative (abnormal content), with about 45-50% linked to neurological issues and 20% to metabolic or infectious origins.
- Quick recognition of warning signs ("red flags") and immediate treatment in a shock room are crucial for managing these medical emergencies.
Renal allograft failure resulting from diffuse cortical necrosis.
Indian J Pathol Microbiol
June 2024
Department of Pathology, Uropathology Division, Surgical Pathology Laboratory, Seth G.S. Medical College and K.E.M Hospital, Parel, Mumbai, Maharashtra, India.
Cortical necrosis of the renal allograft is an extremely rare but serious complication of renal transplantation and can lead to graft failure. Few cases have been reported in the literature to date. We present a rare case of a 28-year-old woman with chronic kidney disease for the past four years who was on biweekly hemodialysis and referred to our tertiary care center for a living-related renal transplant.
View Article and Find Full Text PDFMatrix metalloproteinase-9 (MMP-9) is involved in tissue remodeling and in skin wound healing. The present study focuses on the MMP-9 expression in epidermal wound healing within 1 h after injury, to test whether MMP-9 can be used to estimate the time of injury in forensic practice.A sample consisting of 5 individuals undergoing surgery was analyzed.
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