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Fertility in transgender and gender diverse people: systematic review of the effects of gender-affirming hormones on reproductive organs and fertility.
Hum Reprod Update
January 2025
Amsterdam UMC, Location Vrije Universiteit Amsterdam, Centre of Expertise on Gender Dysphoria, Amsterdam, The Netherlands.
Background: Transgender and gender diverse (TGD) people seek gender-affirming care at any age to manage gender identities or expressions that differ from their birth gender. Gender-affirming hormone treatment (GAHT) and gender-affirming surgery may alter reproductive function and/or anatomy, limiting future reproductive options to varying degrees, if individuals desire to either give birth or become a biological parent.
Objective And Rationale: TGD people increasingly pursue help for their reproductive questions, including fertility, fertility preservation, active desire for children, and future options.
Effect of curcumin on lipid mediators, glycemic index, and oxidative stress and inflammation biomarkers in polycystic ovary syndrome: Future directions and current knowledge - A systematic review.
Prostaglandins Other Lipid Mediat
January 2025
Department of Biology, College of Education For Pure Sciences, University of Anbar, Ramadi, Anbar 31001, Iraq.
Polycystic ovary syndrome (PCOS) is one of the most common and important polygenic endocrine disorders among women of reproductive-aged. Current treatments are mostly used only to control the signs and symptoms of the disease, while not being able to completely prevent complications. Curcumin is one of the active compounds in turmeric, which is commonly used for a wide range of metabolic and inflammatory diseases.
View Article and Find Full Text PDFNanotechnology-Driven Delivery of Caffeine Using Ultradeformable Liposomes-Coated Hollow Mesoporous Silica Nanoparticles for Enhanced Follicular Delivery and Treatment of Androgenetic Alopecia.
Int J Mol Sci
November 2024
Thammasat University Research Unit in Smart Materials and Innovative Technology for Pharmaceutical Applications (SMIT-Pharm), Faculty of Pharmacy, Thammasat University, Pathumthani 12120, Thailand.
Article Synopsis
- Androgenetic alopecia (AGA) is a hair loss condition linked to the hormone dihydrotestosterone (DHT), and the study focuses on enhancing caffeine delivery to hair follicles to counteract its effects.
- Researchers developed a new drug delivery system using caffeine-loaded hollow mesoporous silica nanoparticles coated with ultradeformable liposomes (ULp-Caf@HMSNs), which improve caffeine's ability to penetrate skin and reduce hair loss.
- Results showed that this new system is non-toxic to hair follicle cells, increases cell viability, and effectively reduces harmful oxidative stress in cells affected by DHT, making it a promising alternative to existing treatments like minoxidil.
Efficient, High-Quality Engineering of Therapeutic Extracellular Vesicles on an Integrated Nanoplatform.
ACS Nano
November 2024
Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University; Beijing 100191, China.
Article Synopsis
- Engineered extracellular vesicles (EVs) are gaining attention as therapeutics for gene and cell therapy, but current methods struggle with producing high-quality EVs and precise control over their therapeutic delivery.
- The PURE nanoplatform facilitates efficient electro-transfection, improving EV production while maintaining a suitable extracellular environment, achieving significantly higher yields and therapeutic content compared to natural EVs.
- The effectiveness of PURE-engineered miR-130a-EVs was demonstrated by enhancing ovary function in aged mice, showcasing its potential for clinical applications in EV-mediated therapies.
Transplantation of human umbilical cord-derived mesenchymal stem cells improves age-related ovarian functional decline via regulating the local renin-angiotensin system on inflammation and oxidative stress.
Stem Cell Res Ther
October 2024
Reproductive Medicine Center, First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, China.
Background: Age-related reproductive aging is a natural and irreversible physiological process, and delaying childbearing is increasingly common all over the world. Transplantation of mesenchymal stem cells (MSCs) is considered a new and effective therapy to restore ovarian function, but the relevant mechanisms remain unclear. Recently, it has been found that there is a local Renin-angiotensin system (RAS) in human ovary and it plays a key role.
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