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Background: Yes-associated protein (YAP) is a crucial mechanosensor involved in mechanotransduction, but its role in regulating mechanical force-induced bone remodeling during orthodontic tooth movement (OTM) is unclear. This study aims to elucidate the relationship between mechanotransduction and mechanical force-induced alveolar bone remodeling during OTM.

Results: Our study confirms an asynchronous (temporal and spatial sequence) remodeling pattern of the alveolar bone under mechanical force during OTM.

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Milling chatter, a form of self-excited vibration, can cause significant damage in machining and manufacturing processes. By selecting appropriate milling parameters, milling chatter can be effectively mitigated without sacrificing milling efficiency. Within the framework of the semi-discretization scheme, this paper introduces the Newton-Simpson-based predictor-corrector methods to compute milling stability lobe diagrams.

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Atypical diabetes arising from SHORT syndrome: a case report.

Front Endocrinol (Lausanne)

December 2024

Department of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.

Short stature, joint hyperextension, ocular hypotension, Rieger abnormalities, and delayed tooth eruption (SHORT) syndrom is a rare primary autosomal dominant genetic disorder mainly caused by pathogenic loss-of-function variants in the phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1) gene. We report the case of a Chinese adult female patient with SHORT syndrome, carrying a PIK3R1 gene variant (c.1945C > T), who developed abnormal glucose metabolism and severe postprandial insulin resistance over 9 years.

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Immediate Implant Placement in a Hypothyroid Geriatric Patient: Aesthetic Excellence, Secondary Stability, and Successful Outcome-A Case Report.

Plast Aesthet Nurs (Phila)

December 2024

Sowmya Srinivas, BDS, MDS, PhD, is an Assistant Professor at the Department of Prosthodontics, JSS Dental College and Hospital, JSS Academy of Higher Education and Research, Mysore, Karnataka, India.

Placing an implant immediately into extraction sockets provides a distinct advantage over delayed placement, eliminating the need for a 4 to 6 months waiting period for bone formation. However, when patients present with hypothyroidism, the feasibility of immediate placement of dental implants becomes uncertain. This case involved a hypothyroid woman in her late 60s with loose lower anterior teeth.

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Ludwig's angina is a potentially fatal condition characterized by a rapid onset of cellulitis that bilaterally involves the submandibular, sublingual, and submental spaces. This report describes the case of a 29-year-old female who presented to us with Ludwig's angina following a tooth extraction performed by a traditional healer in Southwestern Uganda. The patient stayed home for over a week before she could seek formal treatment, and this delay led to severe infection and necrotizing fasciitis with extensive tissue necrosis.

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