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A Novel VIM-Type Metallo-β-Lactamase Variant, VIM-60, with Increased Hydrolyzing Activity against Fourth-Generation Cephalosporins in Pseudomonas aeruginosa Clinical Isolates in Japan.
Antimicrob Agents Chemother
June 2019
Department of Microbiology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
A novel VIM-type metallo-β-lactamase variant, VIM-60, was identified in multidrug-resistant clinical isolates in Japan. Compared with VIM-2, VIM-60 had two amino acid substitutions (Arg228Leu and His252Arg) and higher catalytic activities against fourth-generation cephalosporins. The genetic context for was - on the chromosome.
View Article and Find Full Text PDFClinical efficacy of cycling empirical antibiotic therapy for febrile neutropenia in pediatric cancer patients.
J Infect Chemother
July 2017
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department Perinatal and Pediatric Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Article Synopsis
- Febrile neutropenia (FN) is a major cause of mortality in children with cancer, partly due to the risk of antibiotic resistance from prolonged antibiotic use.
- A study conducted between 2011 and 2014 assessed the impact of antibiotic cycling on 126 pediatric cancer patients undergoing treatment.
- Results showed a significant reduction in the detection of antibiotic-resistant bacteria in blood and stool cultures after implementing antibiotic cycling.
Clinical manifestations and bacteriological features of culture-proven Gram-negative bacterial arthritis.
J Microbiol Immunol Infect
August 2017
Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan, Taiwan; Department of Nursing, Min-Hwei College of Health Care Management, Tainan, Taiwan. Electronic address:
Background/purpose: To investigate the clinical manifestations and bacteriological features of culture-proven, Gram-negative bacterial arthritis.
Methods: This study was conducted at the Chi Mei Medical Center, a 1300-bed teaching hospital located in southern Taiwan. Patients with synovial fluid cultures positive for Gram-negative bacilli (GNB) during the period January 2009 to May 2014 were identified from the hospital's computerized microbiology database.
Occurrence of Plasmid-Mediated AmpC β-Lactamases Among Escherichia coli and Klebsiella pneumoniae Clinical Isolates in a Tertiary Care Hospital in Bangalore.
Indian J Microbiol
June 2012
Department of Microbiology, Center for PG Studies, Jain University, 18/3, 9th Main, Jayanagar 3rd Block, Bangalore, 560011 Karnataka India.
Therapeutic options for infections caused by gram-negative organisms expressing plasmid-mediated AmpC β-lactamases are limited because these organisms are usually resistant to all the β-lactam antibiotics, except for cefepime, cefpirome and the carbapenems. These organisms are a major concern in nosocomial infections and should therefore be monitored in surveillance studies. Hence, this study was aimed out to determine the prevalence of plasmid-mediated AmpC β-lactamases in E.
View Article and Find Full Text PDF[Emergence of plasmid mediated AmpC β-lactamasas: Origin, importance, detection and therapeutical options].
Rev Esp Quimioter
June 2012
Servicio de Microbiología, Hospital Clínico Universitario Lozano Blesa, Avda San Juan Bosco 15, 50009 Zaragoza, Spain.
AmpC β-lactamases can hydrolyze penicillins, oxyimino-, 7-α-methoxycephalosporins and monobactams. Susceptibility to cefepime or cefpirome is little affected and is unchanged for carbapenems. Originally such genes are thought to have been mobilized to mobile genetic elements from the chromosomal ampC genes from members of Enterobacteriaceae facilitating their spread and now they can appear in bacterial lacking or poorly expressing a chromosomal ampC gene.
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