AI Article Synopsis
- Increased gamma delta T cells were observed in the peritoneal cavity of LPS-responsive C3H/HeN mice following E. coli infection, while LPS-hyporesponsive C3H/HeJ mice did not show this increase.
- The gamma delta T cells mainly expressed Vgamma6 and Vdelta1 chains and produced significant amounts of gamma interferon in response to LPS.
- The study indicates that IL-15 is involved in promoting the presence of gamma delta T cells, which are crucial for effective defense against E. coli infections.
Article Abstract
The number of gamma delta T cells in the peritoneal cavity was increased after an intraperitoneal (i.p.) infection with Escherichia coli in lipopolysaccharide (LPS)-responsive C3H/HeN mice but not in LPS-hyporesponsive C3H/HeJ mice. The gamma delta T cells preferentially expressed invariant Vgamma6 and Vdelta1 chains and proliferated to produce a large amount of gamma interferon in the presence of LPS. Mice depleted of gamma delta T cells by T-cell receptor delta gene mutation showed impaired resistance against E. coli as assessed by bacterial growth. Macrophages from C3H/HeN mice infected with E. coli expressed higher levels of interleukin-15 (IL-15) mRNA than those from the infected C3H/HeJ mice. Administration of anti-IL-15 monoclonal antibody inhibited, albeit partially, the appearance of gamma delta T cells in C3H/HeN mice after E. coli infection and diminished the host defense against the infection. These results suggest that LPS-stimulated gamma delta T cells play an important role in the host defense against E. coli infection and that IL-15 may be partly involved in the protection via an increase in the gamma delta T cells.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC108342 | PMC |
| http://dx.doi.org/10.1128/IAI.66.7.3270-3278.1998 | DOI Listing |
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