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Regulation of epidermal barrier function and pathogenesis of psoriasis by serine protease inhibitors.
Front Immunol
December 2024
Shanxi Key Laboratory of Stem Cells for Immunological Dermatosis, Institute of Dermatology, Taiyuan Central Hospital, Taiyuan, China.
Serine protease inhibitors (Serpins) are a protein superfamily of protease inhibitors that are thought to play a role in the regulation of inflammation, immunity, tumorigenesis, coagulation, blood pressure and cancer metastasis. Serpins is enriched in the skin and play a vital role in modulating the epidermal barrier and maintaining skin homeostasis. Psoriasis is a chronic inflammatory immune-mediated skin disease.
View Article and Find Full Text PDFAltered neurovascular coupling and structure-function coupling in Moyamoya disease affect postoperative collateral formation.
Sci Rep
December 2024
Department of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Jiefang Road 88th, Hangzhou, 310009, China.
Chronic ischemia in moyamoya disease (MMD) impaired white matter microstructure and neural functional network. However, the coupling between cerebral blood flow (CBF) and functional connectivity and the association between structural and functional network are largely unknown. 38 MMD patients and 20 sex/age-matched healthy controls (HC) were included for T1-weighted imaging, arterial spin labeling imaging, resting-state functional MRI and diffusion tensor imaging.
View Article and Find Full Text PDF[Effects of Different Modified Corn Straw Biochar on Soil Hydraulic Properties in Hilly Loess Areas].
Huan Jing Ke Xue
November 2024
College of Resources and Environment, Shanxi Agricultural University, Taigu 030800, China.
Article Synopsis
- The study examines how modified corn straw biochar impacts water-related soil properties by preparing biochar through pyrolysis and modifying it with specific solvents.
- Various tests were conducted to analyze soil hydraulic conductivity, water evaporation, and moisture content using different concentrations and amounts of biochar.
- Results indicated that adding modified biochar significantly reduced soil hydraulic conductivity, improved water retention, and affected evaporation rates, providing insights for enhancing soil water retention in arid regions.
Bioactive NbC MXene-Functionalized Hydrogel with Microenvironment Remodeling and Enhanced Neurogenesis to Promote Skeletal Muscle Regeneration and Functional Restoration.
Small
October 2024
School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi'an, 710129, P. R. China.
The complete structure-functional repair of volumetric muscle loss (VML) remains a giant challenge and biomedical hydrogels to remodel microenvironment and enhance neurogenesis have appeared to be a promising direction. However, the current hydrogels for VML repair hardly achieve these two goals simultaneously due to their insufficient functionality and the challenge in high-cost of bioactive factors. In this study, a facile strategy using NbC MXene-functionalized hydrogel (OPTN) as a bioactive scaffold is proposed to promote VML repair with skeletal muscle regeneration and functional restoration.
View Article and Find Full Text PDFOptimisation of dry heat treatment conditions for modification of faba bean ( L.) starch.
Heliyon
August 2024
Centre of Excellence in Agri-Food Technologies, National Centre for Food Manufacturing, University of Lincoln, Holbeach, PE12 7PT, UK.
Article Synopsis
- - Faba bean starch (FBS) can be improved using dry heat treatment (DHT), which enhances its functional properties while being eco-friendly, and the study looked at how varying temperature (100-150 °C) and time (0.5-5 h) affect these attributes.
- - The results showed that DHT increased viscosity measures like peak, final, and setback while decreasing amylose content, but did not change the starch's color, structure, or crystallinity significantly.
- - The best DHT conditions for improving FBS were found to be 100 °C for about 0.1716 hours, achieving a desirability factor of 66%, making it more effective than corn starch in certain
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