Objective: To determine whether increased sympathetic vasoconstrictor drive to the calf in heart failure is associated with reduced symptom-limited submaximal exercise performance.
Design: Blood pressure, heart rate and peroneal muscle sympathetic nerve activity (MSNA) were recorded during rest and before symptom-limited treadmill exercise at 70% of resting heart rate reserve for up to 45 mins.
Patients: Thirteen young patients with dilated cardiomyopathy (age 36 +/- 2 years).
Results: MSNA (45 +/- 6 bursts/min) was more than double the level documented in an age-, sex- and weight-matched group of normal subjects studied under identical baseline conditions. Patients with ventricular dysfunction exercised for 30 +/- 3 mins on average, but exercise distance and duration were independent of resting MSNA.
Conclusions: In young patients with dilated cardiomyopathy, sympathetic nerve traffic to the calf vascular bed, measured at rest, does not predict the distance or duration of symptom-limited submaximal treadmill exercise.
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