Diffusely reduced 99Tc(m)-pertechnetate uptake is a relatively infrequent but annoying finding that impairs evaluation of the thyroid gland. We studied 32 female patients aged 19-85 years with markedly reduced pertechnetate uptake. The following causes of reduced pertechnetate uptake were recognized: treatment with iodinated pharmaceuticals (n = 15), suppression therapy with T4 (n = 11), subacute thyroiditis (n = 5) and massive tumour replacement (n = 1). 99Tc(m)-MIBI thyroid scintigraphy was performed within 24 h of the pertechnetate study. The results were correlated with neck ultrasound, serum TSH (n = 25) and surgical findings in patients who had been operated on. The technique identified the following conditions: normally sized thyroids (n = 4), diffuse goitres (n = 8), multinodular goitres (n = 17) and solitary thyroid nodules (n = 3). Moreover, substernal goitres were identified in nine patients. This condition was confirmed at surgery in seven patients. Ultrasonography was concordant in 29 of 32 patients in terms of thyroid size and structure, but failed to demonstrate substernal thyroid tissue. Our results suggest that 99Tc(m)-MIBI scintigraphy may contribute to the diagnosis of thyroid pathology and treatment planning in patients with diffusely decreased 99Tc(m)-pertechnetate uptake.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/00006231-199803000-00010 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of methimazole withdrawl period on the I-131 uptake estimation using Tc-99m thyroid scanning in Graves' disease.
J Clin Endocrinol Metab
November 2024
Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China.
Purpose: The effect of methimazole withdrawl period (MWP) on the estimation of 24 hour-radioiodine thyroid uptake (131IU24h) from 99mTc-pertechnetate thyroid uptake (99mTcTU) remains unclear for patients with Graves disease (GD) . This study aims to investigate the feasibility and reliability of 99mTcTU-based 131IU24h estimation with different MWPs.
Methods: We enrolled 116 GD patients scheduled for 131I therapy at our hospital between April 2022 and April 2023.
Artificial intelligence-based CT-free quantitative thyroid SPECT for thyrotoxicosis: study protocol of a multicentre, prospective, non-inferiority study.
BMJ Open
October 2024
Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea
Introduction: Technetium thyroid uptake (TcTU) measured by single-photon emission CT/CT (SPECT/CT) is an important diagnostic tool for the differential diagnosis of Graves' disease and destructive thyroiditis. Artificial intelligence (AI) may reduce CT-induced radiation exposure by substituting the role of CT in attenuation correction (AC) and thyroid segmentation, thus realising CT-free SPECT. This study aims to compare the diagnostic accuracy for the differential diagnosis of thyrotoxicosis between CT-free SPECT and SPECT/CT.
View Article and Find Full Text PDFA Challenging Case of Hyperfunctioning Submandibular Ectopic Thyroid Successfully Treated With 131 I.
Clin Nucl Med
November 2024
Nuclear Medicine Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Article Synopsis
- Ectopic thyroid tissue is a rare developmental anomaly resulting from issues during the thyroid gland's formation, which can lead to various thyroid-related health problems, including tumors.
- The case presented highlights a woman with recurring hyperthyroidism who had previous thyroid surgeries, and imaging indicated a suspicious area that could be either a salivary gland tumor or ectopic thyroid tissue.
- After thorough clinical evaluation and histopathological analysis, the diagnosis confirmed hyperfunctioning submandibular ectopic thyroid tissue, which was successfully treated using radioactive iodine therapy (131I).
Enhanced Differentiation of Amiodarone-Induced Thyrotoxicosis Types Using Semi-Quantitative 99mTc-MIBI Uptake Analysis: A Pilot Study.
Med Sci Monit
September 2024
Department of Nuclear Medicine, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.
Article Synopsis
- The study investigates the effectiveness of technetium-99m (99mTc)-labelled Methoxy-2-Isobutylisonitrile (MIBI) in diagnosing amiodarone-induced thyrotoxicosis (AIT) through various medical tests, including thyroid scintigraphy and ultrasonography.
- It included 36 AIT patients who underwent multiple analyses, and results showed that semi-quantitative MIBI analysis was more effective in differentiating between AIT subtypes compared to visual analysis.
- The findings suggest that while visual analysis is helpful, semi-quantitative methods provide improved accuracy, indicating the need for larger studies to standardize diagnostic approaches.
Efficacy of Anti-Thyroid Medications in Patients with Graves' Disease.
BMC Endocr Disord
September 2024
College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, 22490, Saudi Arabia.
Article Synopsis
- - Graves' disease is an autoimmune disorder causing hyperthyroidism, often treated with anti-thyroid drugs (ATD), radioactive iodine, or surgery, but data on long-term remission with ATD in Saudi Arabia is limited.
- - A study of 189 patients treated with ATD showed that 54.5% achieved remission, with those in remission having lower free T4 levels and TRAb titers compared to non-remitters.
- - Out of the patients who achieved remission, 34% relapsed after stopping ATD, with relapsing patients showing higher thyroid uptake on scans and longer duration of ATD treatment compared to non-relapsers.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!