A study was made of duodenobiopsies from patients with duodenal ulcer, 62 of whom took part in the elimination of the effects of the Chernobyl Nuclear Power Plant accident, 33 have been resident in the territories affected by radioactive contamination, and 36 were a group of nosological control. In the ChNPP accident victims, the inflammatory process in chronic duodenitis tended to be more pronounced and active, with the atrophic changes in the mucous membrane being more commonly seen. Incorporation of radionuclides and external irradiation in a dose exceeding 25 sGy causes most profound disturbances in regeneration of epithelium entailing metaplasia and dysplasia of gastric epithelium in duodenum, which facts heighten the risk for neoplasmogenesis.
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