Seven cases of pneumatosis cystoides intestinalis affecting the colon (PKC) revealed 5 times by a nonspecific symtomatology and 2 times by an occlusion were reported. In three of the patients the disease was found as a primary idiopathic form free of clinical antecedents. In 4 of the patients the pneumatosis was found to be secondary to a pulmonary disease, a gastric ulcer, a connectivite of a corticotherapy. The PKC was generally diagnosed either by barium enema or by computed tomography and less frequently by colonoscopy with deep biopsy allowing differential diagnosis with colonic polyposis. The mechanism and etiology of the PKC were not fully understood. The illness is a benign condition that often responds to a conservative management--i.e. abstention, oxygenotherapy, diet or antibiotherapy- or exceptionally to surgical colonic resection in case of acute complication.
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Cureus
February 2025
Internal Medicine, University of Florida College of Medicine, Ascension Sacred Heart, Pensacola, USA.
Pneumatosis intestinalis (PI) is a rare but potentially serious gastrointestinal condition with diverse clinical presentations. Pneumatosis intestinalis is identified by the presence of gas in the extraluminal intestinal wall and is further subclassified into benign pneumatosis intestinalis (BPI) and life-threatening pneumatosis intestinalis (LTPI). Prompt and accurate diagnosis, often aided by imaging studies, is crucial to guide appropriate management.
View Article and Find Full Text PDFWorld J Clin Cases
March 2025
Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833401, Taiwan.
Background: Acute mesenteric ischemia is a life-threatening disease. Intrasplenic gas is an extremely rare finding in such cases.
Case Summary: We report a case of a 79-year-old woman with a history of end-stage renal disease on hemodialysis for approximately 20 years, type 2 diabetes mellitus, and atrial fibrillation who presented with two days of epigastric pain.
Front Endocrinol (Lausanne)
February 2025
Department of Radiology, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, Guangdong, China.
Purpose: Pneumatosis intestinalis (PI) is a rare but significant side effect associated with the use of alpha-glucosidase inhibitor (αGI) in the treatment of diabetes. This study aims to analyze the clinical features of PI induced by αGIs in patients with type 2 diabetes mellitus.
Methods: We conducted a retrospective analysis of patients diagnosed with PI between January 2018 and December 2023.
ANZ J Surg
February 2025
Upper Gastrointestinal Surgery Unit, Eastern Health, Melbourne, Victoria, Australia.
Background: Pneumatosis intestinalis, characterised by the presence of intramural bowel gas, is a radiological finding with varied clinical implications, ranging from incidental detection to severe underlying pathology, including bowel ischaemia or perforation. Its association with systemic sclerosis, a connective tissue disorder, remains rare and poorly understood, presenting unique diagnostic and therapeutic challenges.
Methods: A comprehensive literature review was conducted, analysing 34 documented cases of pneumatosis intestinalis associated with systemic sclerosis, examining demographic profiles, clinical features, diagnostic findings, and outcomes of various management strategies.
Turk J Pediatr
December 2024
Division of Neonatology, Department of Pediatrics, Koç University School of Medicine, İstanbul, Türkiye.
Background: Pneumatosis intestinalis (PI) is a rare radiological finding that may be associated with various diseases. In the neonatal period, it is considered pathognomonic for necrotizing enterocolitis (NEC). Cow's milk protein allergy (CMA) is the main cause of allergy especially in term infants appearing following breastfeeding or consumption of milk-based formulas.
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