The scanning probe microscopies provide a unique view of biological and biomedical systems at a nanoscale appropriate to appreciate molecular events. The advent of these methods has brought the ability to acquire quantitative information at the molecular level. Given the proliferation of microscopes and associated methods, the probability for important discoveries is high. If tempered with an appreciation for the potential for artifacts, the SPMs may revolutionize our view of biological systems and biomaterials interactions with those systems.
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http://dx.doi.org/10.1111/j.1749-6632.1997.tb52188.x | DOI Listing |
J Neurol Surg B Skull Base
February 2025
Department of Neurosurgery, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Türkiye.
The absence of precise landmarks in the middle fossa floor and frequent anatomical variations make it difficult to localize the internal acoustic canal (IAC) during the middle fossa approach (MFA). We aimed to investigate the reliability and utility of the neuronavigation system (NNS) in the MFA and to delineate specific technical considerations regarding NNS during the approach. One-millimeter-thin section computed tomography scans were performed on five formalin-fixed human cadavers (10 sides).
View Article and Find Full Text PDFAnal Chem
January 2025
Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, Pennsylvania 15260, United States.
The nuclear pore complex (NPC) is the proteinous nanopore that solely regulates molecular transport between the nucleus and cytoplasm of a eukaryotic cell. Hypothetically, the NPC utilizes the hydrophobic barriers based on the repeats of phenylalanine-glycine (FG) units to selectively and efficiently transport macromolecules. Herein, we quantitatively assess the hydrophobicity of transport barriers confined in the nanopore by applying scanning electrochemical microscopy (SECM).
View Article and Find Full Text PDFInt Dent J
January 2025
Department of Stomatology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. Electronic address:
Introduction And Aim: The assessment of gingival inflammation surface features mainly depends on subjective judgment and lacks quantifiable and reproducible indicators. Therefore, it is a need to acquire objective identification information for accurate monitoring and diagnosis of gingival inflammation. This study aims to develop an automated method combining intraoral scanning (IOS) and deep learning algorithms to identify the surface features of gingival inflammation and evaluate its accuracy and correlation with clinical indicators.
View Article and Find Full Text PDFJ Am Chem Soc
January 2025
Tsung-Dao Lee Institute, Shanghai Jiao Tong University, Shanghai 201210, China.
The emergence of spinon quasiparticles, which carry spin but lack charge, is a hallmark of collective quantum phenomena in low-dimensional quantum spin systems. While the existence of spinons has been demonstrated through scattering spectroscopy in ensemble samples, real-space imaging of these quasiparticles within individual spin chains has remained elusive. In this study, we construct individual Heisenberg antiferromagnetic spin-1/2 chains using open-shell [2]triangulene molecules as building blocks.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Ophthalmology, Gavin Herbert Eye Institute, University of California Irvine, Irvine, California, United States of America.
Purpose: This study aims to explore the feasibility and performance of three-dimensional ultrasound (3DUS) imaging in ophthalmology using commercially available ultrasound probes adapted to a slit lamp.
Significance: Despite ultrasound's long-standing application in eye care for visualizing ocular components, the evolution of 3DUS technology has remained inactive, with limited development and commercial availability. This study introduces a novel method that could potentially enhance ophthalmic diagnostics and treatment planning by providing comprehensive 3D views of ocular structures using existing ultrasound probes adapted to the conventional slit lamp.
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