Oxygen supply systems may be divided into constant and variable performance systems. As the variable performance systems are widely used, it is relevant to investigate the variation in performance between devices and the influence of oxygen supply on the inspired oxygen fraction. Data were collected from 10 healthy volunteers during the use of one constant performance system and four variable performance systems at different gas flows and inspired oxygen fractions. A thin sampling catheter was placed in the nasopharynx to allow the measurement of the end-tidal oxygen fraction. When oxygen was supplied to variable performance systems, end-tidal oxygen fraction values measured in this way varied less and were more easily quantifiable than inspired oxygen fraction. End-tidal oxygen fraction was used to calculate inspired oxygen fraction. With the variable performance systems, inspired oxygen fraction varied considerably between subjects whereas a constant and equal rise was found for each subject with the fixed performance system. A large nasal catheter was capable of delivering the highest inspired oxygen fraction, whereas the Venturi mask delivered the most precise inspired oxygen fraction. We found oxygraphy useful in the interpretation of measurements made in patients receiving unknown inspired fractions of oxygen.
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http://dx.doi.org/10.1046/j.1365-2044.1998.00318.x | DOI Listing |
Free Radic Biol Med
January 2025
Department of Radiation Oncology, Mays Cancer Center at UT Health San Antonio MD Anderson, Joe R. and Teresa Lozano Long School of Medicine, TX, USA. Electronic address:
Manganese superoxide dismutase (MnSOD/SOD2) is an essential mitochondrial enzyme that detoxifies superoxide radicals generated during oxidative respiration. MnSOD/SOD2 lysine 68 acetylation (K68-Ac) is an important post-translational modification (PTM) that regulates enzymatic activity, responding to nutrient status or oxidative stress, and elevated levels have been associated with human illness. To determine the in vivo role of MnSOD-K68 in the heart, we used a whole-body non-acetylation mimic mutant (MnSOD) knock-in mouse.
View Article and Find Full Text PDFJ Thorac Cardiovasc Surg
January 2025
University of Maryland School of Medicine, Division of Cardiothoracic Surgery. Electronic address:
Objective: Over 30% of patients presenting with acute type A aortic dissection (ATAAD) are considered high - risk or inoperable. This study aims to investigate the early and mid-term outcomes of complex endovascular aortic repair of aortic root, ascending aorta, and aortic arch among patients with ATAAD.
Methods: From January 2018 to January 2023, 29 patients who were considered high risk for open operation underwent endovascular aortic repair.
Rev Port Cardiol
January 2025
Cardiology Department, Santa Cruz Hospital, Lisbon, Portugal; Cardiac Rehabilitation Unit, Santa Cruz Hospital, Lisbon, Portugal.
Introduction And Objectives: Cardiopulmonary exercise testing (CPET) is the gold standard for quantifying aerobic functional capacity, yet it is costly and not widely available. The CLINIMEX Aerobic Fitness Questionnaire (C-AFQ) may be a practical alternative as it estimates oxygen consumption at peak exercise (VO peak) based on patients' responses to a list of activities with known energy requirements. However, its applicability in cardiac patients is unclear and has not yet been studied.
View Article and Find Full Text PDFJ Contam Hydrol
January 2025
USDA ARS, National Soil Erosion Research Laboratory, West Lafayette, IN 47907, United States of America.
Agricultural phosphorus (P) losses may result from either recently applied fertilizers or from P accumulated in soil and sediment. While both P sources pose an environmental risk to freshwater systems, differentiating between sources is crucial for identifying and implementing management practices to decrease loss. In this study, laboratory rainfall simulations were completed on runoff boxes and undisturbed soil columns before and after fertilizer application.
View Article and Find Full Text PDFClin Transplant
January 2025
Division of Cardiac Surgery, Department of Surgery, Faculty of Medicine, University of Alberta, Edmonton, Canada.
Introduction: Preclinically, 24-hour continuous Ex-Situ Lung Perfusion (ESLP) is the longest duration achieved in large animal models and rejected human lungs. Here, we present our 36-hour Negative Pressure Ventilation (NPV)-ESLP protocol applied to porcine and rejected human lungs.
Methods: Five sets of donor domestic pig lungs (45-55 kg) underwent 36-hour NPV-ESLP.
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