According to the statistics prepared by health insurance carriers community-acquired pneumonia has an incidence of some 300,000 to 400,000 cases per year. In old age (more than 80 years), the mortality rate increases from 20 to 2000 per 100,000 head of the population, that is, by a factor of 100. The former classification into "typical" and "untypical" pneumonia has now been abandoned, the modern approach being that of "calculated antibiotic therapy" that involves the placing of patients in "risk groups". To each risk group a probable pathogen spectrum is assigned and a recommendation for the selection of an appropriate antibiotic then made. Thus, for example, for the pathogen spectrum in group 1 (ambulatory patients under 60 years of age and no major secondary diseases), the macrolides are the antibiotics of first choice. The procedure to be followed in the other risk groups and in the event of treatment failures is discussed. Criteria that identify the need for hospitalization are presented.
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Neurology
February 2025
Division of Clinical and Metabolic Genetics, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Ontario, Canada.
Pathogenic variants in cause congenital muscular dystrophy through hypoglycosylation of alpha-dystroglycan (OMIM #615350). The established phenotypic spectrum of GMPPB-related disorders includes recurrent rhabdomyolysis, limb-girdle muscular dystrophy, neuromuscular transmission abnormalities, and congenital muscular dystrophy with variable brain and eye anomalies. We report a 9-month-old male infant with congenital muscular dystrophy, infantile spasms, and compound heterozygous pathogenic variants (c.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Pharmaceutical Biotechnology and Biotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Bovine mastitis is a considerable challenge within the dairy industry, causing significant financial losses and threatening public health. The increased occurrence of methicillin-resistant Staphylococcus aureus (MRSA) has provoked difficulties in managing bovine mastitis. Bacteriophage therapy presents a novel treatment strategy to combat MRSA infections, emerging as a possible substitute for antibiotics.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.
Cotton textiles with persistent antibacterial qualities are crucial in halting the spread of bacteria and other infections. However, fugitive bacteria and drug-resistant pathogens have rendered tremendous challenges in the development of cotton fabrics with long-lasting antibacterial efficacy. The work aimed to innovatively propose a functional cotton fabric integrating intelligent bacteria-capturing and dual antibacterial properties for efficacious personal health management.
View Article and Find Full Text PDFProbiotics Antimicrob Proteins
January 2025
Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture, Setagaya, Tokyo, 156-8502, Japan.
European foulbrood (EFB) is a bee larvae-specific infectious disease and the causative pathogen is Melissococcus plutonius. Broad-spectrum antibiotics have classically been used in many countries to control the pathogens; however, their use in apiaries was discontinued in several countries due to concerns regarding the health of bees and humans. Therefore, the development of alternative treatments for use in apiaries that are safe for bees and humans is essential.
View Article and Find Full Text PDFMicrobiol Spectr
January 2025
Sunshine Coast Health Institute, Birtinya, Queensland, Australia.
Pleural infections are common and associated with substantial healthcare costs, morbidity, and mortality. Accurate diagnosis remains challenging due to low culture positivity rates, frequent polymicrobial involvement, and non-specific diagnostic biomarkers. Here, we undertook a prospective study examining the feasibility and performance of molecular methods for diagnosing suspected pleural infection.
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