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Patterns of Isoform Variation for N Gene Subgenomic mRNAs in Betacoronavirus Transcriptomes.
Viruses
December 2024
Department of Biology, Center for Computational and Integrative Biology, Rutgers University, Camden, NJ 08102, USA.
The nucleocapsid (N) protein is the most expressed protein in later stages of SARS-CoV-2 infection with several important functions. It is translated from a subgenomic mRNA (sgmRNA) formed by template switching during transcription. A recently described translation initiation site (TIS) with a CTG codon in the leader sequence (TIS-L) is out of frame with most structural and accessory genes including the N gene and may act as a translation suppressor.
View Article and Find Full Text PDFFlexible Vibration Sensors with Omnidirectional Sensing Enabled by Femtosecond Laser-Assisted Fabrication.
Polymers (Basel)
January 2025
State Key Laboratory of Precision Manufacturing for Extreme Service Performance, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China.
Vibration sensors are integral to a multitude of engineering applications, yet the development of low-cost, easily assembled devices remains a formidable challenge. This study presents a highly sensitive flexible vibration sensor, based on the piezoresistive effect, tailored for the detection of high-dynamic-range vibrations and accelerations. The sensor's design incorporates a polylactic acid (PLA) housing with cavities and spherical recesses, a polydimethylsiloxane (PDMS) membrane, and electrodes that are positioned above.
View Article and Find Full Text PDFBased on the Geometric Characteristics of Binocular Imaging for Yarn Remaining Detection.
Sensors (Basel)
January 2025
School of Mechanical Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China.
The automated detection of yarn margins is crucial for ensuring the continuity and quality of production in textile workshops. Traditional methods rely on workers visually inspecting the yarn margin to determine the timing of replacement; these methods fail to provide real-time data and cannot meet the precise scheduling requirements of modern production. The complex environmental conditions in textile workshops, combined with the cylindrical shape and repetitive textural features of yarn bobbins, limit the application of traditional visual solutions.
View Article and Find Full Text PDFNumerical Simulations of Single-Step Holographic Interferometry for Split-Ring Metamaterial Fabrication.
Nanomaterials (Basel)
January 2025
School of Physics and Optoelectronics, South China University of Technology, Guangzhou 510640, China.
Artificial microstructures, especially metamaterials, have garnered increasing attention in numerous applications due to their rich and distinctive properties. Starting from the principle of multi-beam interference, we have theoretically devised a beam configuration consisting of six symmetrically distributed coherent beams to generate two-dimensional microstructures with diverse shapes of unitcells under different polarization combinations. In particular, a split-ring metamaterial template is achieved with two adjacent circularly and four linearly polarized beams with such single-step holographic interferometry.
View Article and Find Full Text PDFSocioeconomic position across the life course and falls among middle- and older-aged adults: protocol for a systematic review.
BMJ Open
January 2025
The University of Sydney School of Public Health, Sydney, New South Wales, Australia
Introduction: Individuals experiencing disadvantaged socioeconomic positions (SEPs) may be at increased risk of falls during middle and older age, and these impacts of socioeconomic factors may vary according to the duration, timing and sequencing of exposures across the life course. However, there has not been a recent systematic review of this evidence. This study, therefore, aims to synthesise existing knowledge on the association between SEP across the life course and falls within middle- and older-aged adults.
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