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Drug Development.
Alzheimers Dement
December 2024
Ahmadu Bello University Zaria, Zaria, Kaduna, Nigeria.
Background: Studies suggest a potential link between stroke and Alzheimer's disease wherein stroke may serve as a trigger for the onset or acceleration of Alzheimer's pathogenesis as damage to the brain's blood vessels may lead to the accumulation of amyloid beta protein which is a hallmark of Alzheimer's disease. Recent research has shown that stroke treatment may hold the key to treating Alzheimer's disease. The anti-inflammatory potentials of Cholinergic signaling are a novel therapeutic target in memory decline associated with Alzheimer's.
View Article and Find Full Text PDFBackground: Understanding the fundamental differences between the human and pre-human brain is a prerequisite for designing meaningful models and therapies for AD. Expressed CHRFAM7A, a human restricted gene with carrier frequency of 75% in the human population predicts profound translational significance.
Method: The physiological role of CHRFAM7A in human brain is explored using multiomics approach on 600 post mortem human brain tissue samples (ROSMAP).
Removal of chlorpyrifos from aqueous medium using Ca-CuO@clay nanoflakes coated with deep eutectic solvent.
Environ Monit Assess
November 2024
Department of Chemistry, Government College University, Lahore, Pakistan.
Availability of fresh water for domestic, industrial, and agricultural use has become a huge challenge in different parts of the world due to continuous contamination. The leaching of different pesticides in agricultural lands is one of the major sources of water contamination that needs to be monitored and countered. The current study was designed to synthesize specific material for the removal of pesticides from aqueous medium.
View Article and Find Full Text PDFDifferential participation of CaMKII/ROCK and NOS pathways in the cholinergic inhibitory drive operated by nicotinic α7 receptors in perisynaptic Schwann cells.
Biochem Pharmacol
January 2025
Laboratório de Farmacologia e Neurobiologia, Instituto de Ciências Biomédicas de Abel Salazar Universidade do Porto (ICBAS-UP), 4050-313 Porto, Portugal; Centro de Investigação Farmacológica e Inovação Medicamentosa (MedInUP/RISE-Health), Instituto de Ciências Biomédicas de Abel Salazar Universidade do Porto (ICBAS-UP), 4050-313 Porto, Portugal. Electronic address:
Nicotinic α7 receptors (α7 nAChRs) present in perisynaptic Schwann cells (PSCs) control acetylcholine (ACh) spillover from the neuromuscular synapse by transiently increasing intracellular Ca, which fosters adenosine release via type 1 equilibrative nucleoside transporters (ENT1) and retrograde activation of presynaptic A inhibitory receptors. The putative Ca-dependent pathways downstream α7 nAChRs involved in the sensing inhibitory drive operated by PSCs is unknown. Herein, we used phrenic nerve-hemidiaphragm preparations from Wistar rats.
View Article and Find Full Text PDFDifficult Differential Diagnosis of Paraneoplastic Neuromuscular Diseases Associated with Small Cell lung Cancer: A Report of Two Cases.
Tokai J Exp Clin Med
December 2024
Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
Article Synopsis
- Lambert-Eaton Myasthenic Syndrome (LEMS) is a neurological condition often associated with small cell lung cancer and shares symptoms with myasthenia gravis (MG), leading to potential misdiagnosis.
- The article presents two cases where patients with small cell lung cancer exhibited LEMS-like symptoms, but had unique electromyographic results that complicated diagnosis.
- Both patients did not respond well to standard treatments for MG and tested positive for a specific antibody linked to LEMS, highlighting the challenges in distinguishing between LEMS and MG based on clinical and EMG criteria.
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