[Microscopic study of species specific features of hemostatic impairment in Ebola virus infected monkeys].

Pathological changes were studied in the blood vessels of baboons, green, rhesus, and cynomolgus monkeys at the end-stage Ebola (Zaire) infection. Marked microvascular lesions (capillary stasis, blood engorgement, thrombosis with blood cells, neutrophil accumulation, endothelial edema) were found in all the monkeys. These changes clearly indicate impaired organ blood supply. Multiple hemorrhages were formed by diapedesis without vascular wall destruction. Fibrin deposition and thrombi were features of hemostatic impairment in green and rhesus monkeys. Fibrin deposition and hemorrhages were not found in the cynomolgus monkeys. The possible mechanisms responsible for end-stage shock in Ebola virus-infection associated with microcirculatory disorders.