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Driver lines for studying associative learning in .
Elife
January 2025
Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
The mushroom body (MB) is the center for associative learning in insects. In , intersectional split-GAL4 drivers and electron microscopy (EM) connectomes have laid the foundation for precise interrogation of the MB neural circuits. However, investigation of many cell types upstream and downstream of the MB has been hindered due to lack of specific driver lines.
View Article and Find Full Text PDFThe signification of the principle of constancy in Freud's psychoanalysis.
Int J Psychoanal
December 2024
Independent Researcher.
This article examines the signification of the principle of constancy in Freud's pre-psychoanalytic drafts and papers and in . It is argued that Freud's principle differs from seemingly similar principles proposed by Breuer and Fechner, and that it constitutes an assumption about the maintaining of a constant amount of mobile biophysical energy whose purpose is to return to equilibrium, but, proceeding from the primary functions of discharge (principle of inertia) and accumulation (exigencies of life), to consolidate an asymmetry within the nervous system. This gives rise to a set of quasi-psychological dualisms: an energetic dualism between kinetic and tonic energy; a systemic dualism between impermeable and permeable neurons; and a processual dualism between courses of the excitation with and without the inhibiting influence of the ego.
View Article and Find Full Text PDFVolitional spatial attention is lateralized in crows.
Proc Biol Sci
January 2025
Animal Physiology Unit, Institute of Neurobiology, University of Tübingen, Auf der Morgenstelle 28, Tübingen 72076, Germany.
Like humans and many other animal species, birds exhibit left-right asymmetries in certain behaviours due to differences in hemispheric brain functions. While the lateralization of sensory and motor functions is well established in birds, the potential lateralization of high-level executive control functions, such as volitional attention, remains unknown. Here, we demonstrate that carrion crows exhibit more pronounced volitional (endogenous) attention for stimuli monocularly viewed with the left eye and thus in the left visual hemifield.
View Article and Find Full Text PDFApplication of copy number variation sequencing combined with whole exome sequencing in prenatal left-right asymmetry disorders.
BMC Genomics
January 2025
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue 1095, Wuhan, Hubei, 430030, China.
Background: Left-right (LR) asymmetry disorders present a complex etiology, with genetic factors emerging as a primary contributor. This study aims to explore the genetic underpinnings of chromosomal variants and individual genes in fetuses afflicted with prenatal LR asymmetry disorder.
Methods: Through a retrospective analysis conducted between 2020 and 2023 at Tongji Hospital, Huazhong University of Science and Technology, genetic outcomes of LR asymmetric disorder were scrutinized utilizing copy number variation sequencing (CNV-seq) and whole exome sequencing (WES) methodologies.
Substrates, regulation, cellular functions, and disease associations of P4-ATPases.
Commun Biol
January 2025
Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto, 606-8501, Japan.
P4-ATPases, a subfamily of the P-type ATPase superfamily, play a crucial role in translocating membrane lipids from the exoplasmic/luminal leaflet to the cytoplasmic leaflet. This process generates and regulates transbilayer lipid asymmetry. These enzymes are conserved across all eukaryotes, and the human genome encodes 14 distinct P4-ATPases.
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