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Plasma myeloperoxidase interactions with cadmium, lead, arsenic, and selenium and their impact on chronic kidney disease.
Ecotoxicol Environ Saf
January 2025
Department of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Family Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. Electronic address:
Myeloperoxidase (MPO) is an oxidative stress biomarker, with elevated MPO levels linked to chronic kidney disease (CKD) progression. Metal exposure is a risk factor for CKD, and is also correlated to MPO expression, with specific MPO genotypes linked to MPO expression. Therefore, we examined whether MPO plasma levels or MPO polymorphisms were linked to CKD, and explored whether these factors modified associations between CKD and metal concentrations.
View Article and Find Full Text PDFCombined effects of global DNA methylation, blood lead and total urinary arsenic levels on developmental delay in preschool children.
Environ Health
January 2025
Department of Family Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
DNA methylation is a critical step in brain development, 5-Methyl-2'-deoxycytidine (5mdC) is one of the global DNA methylation markers. Arsenic and lead exposures have been associated with neurotoxicity, which may be linked to epigenetic changes. Our research sought to investigate the correlation between 5mdC and developmental delay (DD) among preschoolers.
View Article and Find Full Text PDFAntepartum insomnia symptoms and its association with postpartum depression symptoms in women with and without psychiatric vulnerability: A prospective cohort study.
J Affect Disord
January 2025
Department of Psychiatry and Medical Psychology, OLVG, P.O. Box 95500, 1090 HM Amsterdam, the Netherlands; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit van Amsterdam, P.O. Box 7057, 1007 MB Amsterdam, the Netherlands; Amsterdam Public Health, Mental Health Programme, Amsterdam, the Netherlands.
Background: Postpartum depression is common and may be linked to antepartum insomnia, a potentially modifiable risk factor. We examine the association between insomnia- and postpartum depression symptoms, considering whether psychiatric vulnerability moderates this link.
Method: Participants completed the Insomnia Severity Index during trimester two and three and the Hospital Anxiety and Depression questionnaire postpartum.
Distinct network patterns emerge from Cartesian and XOR epistasis models: a comparative network science analysis.
BioData Min
December 2024
School of Computing, Queen's University, 557 Goodwin Hall, 21-25 Union St, Kingston, K7L 2N8, Ontario, Canada.
Background: Epistasis, the phenomenon where the effect of one gene (or variant) is masked or modified by one or more other genes, significantly contributes to the phenotypic variance of complex traits. Traditionally, epistasis has been modeled using the Cartesian epistatic model, a multiplicative approach based on standard statistical regression. However, a recent study investigating epistasis in obesity-related traits has identified potential limitations of the Cartesian epistatic model, revealing that it likely only detects a fraction of the genetic interactions occurring in natural systems.
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