Upper airway obstruction in patients with sleep apnea may occur in the absence of a negative intraluminal upper airway pressure. We hypothesized that surface tension forces may play a role in the pathogenesis of obstructive sleep apnea (OSA), and that a topical soft tissue lubricant might reduce the severity of OSA. Ten male patients (age 49 +/- 10 yr [mean +/- SD]; body mass index [BMI] 31 +/- 5 kg/m2) with OSA (apnea-hypopnea index [AHI] 17 +/- 9) were studied. The arousal index was lower with the lubricant treatment than with placebo (mean difference 8; 95% CI 4 to 11 arousals/h; p = 0.001). The AHI was lower, in each of the 10 patients, on the lubricant treatment than the placebo (mean change 10, 95% CI 6 to 13; p = 0.0003). The lower AHI with lubricant as compared with placebo was present in both supine (mean difference 13; 95% CI 5 to 20; p = 0.006) and nonsupine (mean difference 6; 95% CI 0 to 12; p = 0.05) positions. There was no significant difference in sleep architecture between the lubricant and placebo treatments. Application of a topical lubricant consistently reduced the severity of OSA. This implies a pathogenetic role for surface tension forces in OSA, and a potential role for surface tension-reducing agents in the treatment of OSA.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1164/ajrccm.157.5.9708070 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Interfacial properties of whey protein hydrolysates monitored by quartz crystal microbalance with dissipation.
Int J Biol Macromol
January 2025
Key Laboratory of Dairy Science, Ministry of Education, College of Food Science, Northeast Agricultural University, Harbin 150030, China; Food Laboratory of Zhongyuan, Luohe 462300, Henan, China; Key Laboratory of Infant Formula Food, State Administration for Market Regulation, Harbin 150030, China. Electronic address:
Whey protein hydrolysate (WPH) can be used to develop hypoallergenic foods. However, the stabilization mechanism of WPH-stabilized emulsion is not fully understood. Here, a real-time quartz crystal microbalance with dissipation monitoring (QCM-D) was used in conjunction with a rheometer to investigate the interfacial properties of WPH.
View Article and Find Full Text PDFEnhancement of oil dispersion and marine oil snow formation by surface-active biomasses from diatom.
Mar Environ Res
January 2025
College of Environmental Sciences and Engineering, Dalian Maritime University, Dalian 116026, China. Electronic address:
Following the Deepwater Horizon oil spill event, the formation of marine oil snow (MOS) has attracted much attention from marine environmental scientists. This study investigates the crude oil dispersion as well as the MOS formation in the presence of Phaeodactylum tricornutum and Chaetoceros sp. through laboratory experiments.
View Article and Find Full Text PDFSynergistic binding ability of electrostatic tweezers and femtosecond laser-structured slippery surfaces enabling unusual droplet manipulation applications.
Lab Chip
January 2025
CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, 230027, P. R. China.
We propose a novel contactless droplet manipulation strategy that combines electrostatic tweezers (ESTs) with lubricated slippery surfaces. Electrostatic induction causes the droplet to experience an electrostatic force, allowing it to move with the horizontal shift of the EST. Because both the EST and the slippery operating platform prepared by a femtosecond laser exhibit a strong binding effect on droplets, the EST droplet manipulation features significant flexibility, high precision, and can work under various operating conditions.
View Article and Find Full Text PDFSmart Directional Liquid Manipulation on Curvature-Ratchet Surfaces.
ACS Nano
January 2025
Department of Mechanical Engineering, The University of Hong Kong, Hong Kong, China.
Structured surfaces leverage interfacial energy for directional liquid manipulation without external power, showing tremendous potential in microfluidics, green energy and biomedical applications. While the interplay of interfacial energy between solid surfaces and liquids is crucial for liquid manipulation, a systematic understanding of how the balance in liquid-solid interfacial energy affects liquid behaviors remains lacking. Here, using the curvature-ratchet surface as a generic example, we reveal the complex directional liquid dynamics inherent in the subtle regulation of liquid-solid interfacial energy.
View Article and Find Full Text PDFOn the enhancement of the efficiency of concentrated solar power plants using nanofluids based on a linear silicone fluid and Pt nanoparticles.
Sci Rep
January 2025
Department of Physical Chemistry, University of Cádiz, 11510, Puerto Real, Spain.
To reduce greenhouse emissions and producing electricity with the smallest environmental impact, developing solar power technology is one of the most important milestones to achieve. Thus, to improve the efficiency of the concentrated solar power (CSP) plants, with lower environmental impact, is of great interest. This work reports the development of nanofluids, a colloidal suspension of nanomaterials in a fluid, based on an environment-friendly base fluid for improving the performance of the heat transfer process in CSP plants.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!